885227-79-2Relevant academic research and scientific papers
Hypoxia-activated prodrugs: Substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents
Tercel, Moana,Atwell, Graham J.,Yang, Shangjin,Stevenson, Ralph J.,Botting, K. Jane,Boyd, Maruta,Smith, Eileen,Anderson, Robert F.,Denny, William A.,Wilson, William R.,Pruijn, Frederik B.
supporting information; experimental part, p. 7258 - 7272 (2010/07/13)
Nitrochloromethylbenzindolines (nitroCBIs) are a new class of hypoxia-activated prodrugs for antitumor therapy. The recently reported prototypes undergo hypoxia-selective metabolism to form potent DNA minor groove alkylating agents and are selectively tox
NITROBENZINDOLES AND THEIR USE IN CANCER THERAPY
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Page/Page column 95-99, (2010/11/08)
The present invention relates generally to nitro-1,2-dihydro-3H-benzo[e]indoles and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation a
