885268-39-3

Usage

Uses

Used in Pharmaceutical Research and Development:
2-(4-Fluorophenyl)oxazole is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological effects. Its unique structure allows it to be a promising candidate in the development of new drugs with novel mechanisms of action.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(4-Fluorophenyl)oxazole serves as a valuable building block for the creation of complex organic molecules. Its reactivity and structural features make it suitable for the synthesis of a wide range of compounds with potential applications in various industries.
Used in Medicinal Chemistry:
2-(4-Fluorophenyl)oxazole is employed as a structural motif in medicinal chemistry to design and optimize drug candidates. Its presence in a molecule can modulate pharmacokinetic and pharmacodynamic properties, leading to improved drug efficacy and safety profiles.
Used in Agrochemicals:
2-(4-Fluorophenyl)oxazole may also find applications in the development of agrochemicals, such as pesticides and herbicides, due to its potential biological activities. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds while minimizing environmental impact.

Upstream product

• 133472-27-2 4-fluorophenylzinc chloride 
• 201017-90-5 2-(methylthio)oxazole 
• 288-42-6 oxazol 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 609345-33-7 oxazol-2-ylzinc(II) chloride 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 1429329-80-5 1-(2-(4-fluorophenyl)oxazol-5-yl)-1-(pyridin-4-yl)ethanol 

Relevant academic research and scientific papers

Orientation effects on C2(5)-C2?(5?) linked bioxazole isomers synthesized via regioselective and sequential C[sbnd]H arylation

Bis(4-fluorophenyl) substituted oxazole (2,5-Oxz) and C2(5)-C2?(5?) linked bioxazole isomers (C2-C2?_BOxz, C2-C5?_BOxz and C5-C5?_BOxz) were concisely synthesized via palladium-catalyzed regioselective and sequential C[sbnd]H arylation in 1–3 reaction steps along with 20%–83% of total yields from oxazole and 4-bromofluorobenzene. The linking orientation plays a key role in the packing geometry and photophysical properties of C2-C2'_BOxz, C2-C5'_BOxz and C5-C5'_BOxz. These bioxazole isomers in solid state showed significant differences in photoluminescence quantum yields (PLQY) (0.33, 0.25 and 0.04, respectively), delayed fluorescence properties and powder X-ray diffraction (PXRD) patterns, suggesting the divergence in intermolecular interactions. The theoretically calculated gradient isosurfaces and complexation energies indicate the existence of intense π-π interactions between molecular layers, which are in good agreement with the variation trend of optical properties.

Warming Up to Oxazole: Noncryogenic Oxazole Metalation and Negishi Coupling Development

This report details the development of several suitable noncryogenic metalation conditions for the synthesis of oxazole zincate. Subsequent rounds of high-throughput catalyst screening ultimately led to the identification of several suitable Pd sources th

PYRIDINE DERIVATIVES

The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP 17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.

Nickel-catalyzed synthesis of oxazoles via C-S activation

The synthesis of 2-substituted oxazoles is achieved via nickel-catalyzed cross-coupling reaction of 2-methylthio-oxazole and various organozinc reagents. An extension of this method is demonstrated with a chemoselective, one-pot synthesis of unsymmetrical