885272-74-2

Basic information

• Product Name: (2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE
• Synonyms: (2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE
• CAS NO: 885272-74-2
• Molecular Formula: C16H13N3
• Molecular Weight: 247.29
• Mol File: 885272-74-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE(885272-74-2)
• EPA Substance Registry System: (2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE(885272-74-2)

Safety Data

• Hazardous Substances Data: 885272-74-2(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2-P-Tolyl-imidazo[1,2-a]pyridin-3-yl)-acetonitrile" is a synthetic organic compound that belongs to the imidazo[1,2-a]pyridine class of chemicals. It consists of a pyridine ring fused with an imidazole ring and a p-tolyl group attached to the imidazole ring at position 2. The compound also contains an acetonitrile group, which is a nitrile compound with a methyl group attached to the carbon atom. This chemical may have potential applications in pharmaceutical research, as imidazopyridines are known to exhibit biological activities, including antitumor, antiviral, and neuroprotective effects. Additionally, the presence of the acetonitrile group may provide opportunities for further chemical modifications to enhance its properties for specific applications.

Upstream product

• 65964-60-5 2-para-tolylimidazo[1,2-a]pyridine 
• 590-17-0 cyanomethyl bromide 
• 504-29-0 2-aminopyridine 
• 619-41-0 4-(bromoacetyl)toluene 
• 13138-21-1 diazoacetonitrile 
• 75-05-8 acetonitrile 
• 151-50-8 potassium cyanide 
• 365213-41-8 N,N-dimethyl-1-(2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine 

Relevant articles and documents

Synthesis of C3-Cyanomethylated Imidazo[1,2- a ]pyridines via Ultrasound-Promoted Three-Component Reaction under Catalyst- and Oxidant-Free Conditions

An efficient synthesis of C3-cyanomethylated imidazo[1,2-α]pyridines via ultrasound-promoted three-component reaction under catalyst-free, oxidant-free, and mild conditions has been developed. A series of C3-cyanomethylated imidazo[1,2-α]pyridines were rapidly prepared with satisfactory yields and good functional group compatibility. This strategy cloud also be applied to the synthesis of zolpidem and alpidem in short steps.

FeCl3-catalyzed C-3 functionalization of imidazo[1,2-a]pyridines with diazoacetonitrile under oxidant- and ligand-free conditions

A facile synthesis of 2-(imidazo[1,2-a]pyridin-3-yl)acetonitriles via FeCl3-catalyzed site-selective C(sp2)-H alkylation of imidazo[1,2-a]pyridines with diazoacetonitrile is presented. This new method features with an environmentally benign catalyst, easily obtainable substrates, and oxidant- and ligand-free reaction conditions. Moreover, the importance of the products thus obtained is showcased by their ready transformation into some synthetically and pharmaceutically interesting products with good efficiency.

Visible-Light-Induced Regioselective Cyanomethylation of Imidazopyridines and Its Application in Drug Synthesis

3-Cyanomethylated imidazopyridines were synthesized via a visible light-promoted reaction of imidazopyridines with bromoacetonitrile or iodoacetonitrile catalyzed by fac-Ir(ppy)3 under mild conditions. For the substrates with various substituents on benzene or pyridine ring, the reaction proceeded smoothly to give the corresponding products in moderate to good yields. The synthetic utility of this visible-light-induced reaction has been illustrated in the efficient synthesis of zolpidem and alpidem.