885273-21-2

Usage

Uses

Used in Pharmaceutical Industry:
2-M-TOLYL-OXAZOL-4-YL-METHYLAMINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, potentially enhancing the therapeutic effects and selectivity of resulting drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-M-TOLYL-OXAZOL-4-YL-METHYLAMINE is utilized as a component in the development of new agrochemicals, such as pesticides and herbicides, where its unique properties may contribute to improved efficacy and selectivity in controlling pests and weeds.
Used in Organic Synthesis:
2-M-TOLYL-OXAZOL-4-YL-METHYLAMINE is used as a building block in organic synthesis for the preparation of other organic compounds, leveraging its reactivity and structural features to create novel molecules with specific applications in various industries.
Used in Medicinal Chemistry Research:
Due to its unique structure and properties, 2-M-TOLYL-OXAZOL-4-YL-METHYLAMINE is employed in medicinal chemistry research for the design and development of new drugs, where it may contribute to the discovery of innovative therapeutic agents with improved pharmacological profiles.

Upstream product

• 618-47-3 m-toluamide 
• 1038708-57-4 C₁₁H₁₀ClNO 

Relevant academic research and scientific papers

Design, synthesis, and insecticidal/acaricidal evaluation of novel pyrimidinamine derivatives containing phenyloxazole moiety

A series of novel pyrimidinamine derivatives containing phenyloxazole moiety were designed and synthesized, and their structures were characterized by 1H NMR, MS, and elemental analyses. The bioassay results displayed that some compounds exhibited remarkable insecticidal activities against Aphis fabae and Tetranychus cinnabarinus. Especially, 5-chloro-6-ethyl-2-methyl-N-((2-(p-tolyl)oxazol-4-yl)methyl)pyrimidin-4-amine (9o) showed potent activity against A. fabae, superior to that of the commercial insecticide, imidacloprid. In addition, 5-chloro-6-ethyl-2-methyl-N-((2-(4-(trifluoromethyl)phenyl)oxazol-4-yl)methyl)pyrimidin-4-amine (9r) showed potent activities against T. cinnabarinus, inferior to that of the commercial insecticide spirotetramat. The structure–activity relationship study for the target compounds was also discussed.

Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optimal fungicidal activity, which respectively offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to commercial fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound T18 has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future.