88537-44-4

Upstream product

• 88537-43-3 1-p-toluenesulfonyloxy-3-(4-methoxyphenyl)propane 
• 15823-04-8 methyl 3-(4-methoxyphenyl)propionate 
• 123-11-5 4-methoxy-benzaldehyde 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 
• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 

Downstream Products

• 88537-46-6 3-(4-methoxyphenyl)propyl 4-(4-methoxyphenyl)butyl sulphide 
• 210048-38-7 3-(p-methoxyphenyl)-1-mercaptyl pyrrolidine-2-carboxylate 
• 1448552-70-2 C₁₆H₁₅N₃O₄S 
• 210048-37-6 3-(p-methoxyhenyl)-1-mercaptyl N-(tert-butyloxycarbonyl)pyrrolidine-2-carboxylate 
• 88537-48-8 3-(3-iodo-4-methoxyphenyl)propyl 4-(3-iodo-4-methoxyphenyl)butyl sulphone 
• 88537-47-7 3-(4-methoxyphenyl)propyl 4-(4-methoxyphenyl)butyl sulphone 

Relevant academic research and scientific papers

N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders

This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-linked sulfonamides of heterocyclic thioesters.

Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects

The recent discovery that small molecule ligands for the peptidyl-prolyl isomerase (PPIase) FKBP12 possess powerful neuroprotective and neuroregenerative properties in vitro and in vivo suggests therapeutic utility for such compounds in neurodegenerative disease. The neurotrophic effects of these compounds are independent of the immunosuppressive pathways by which drugs such as FK506 and rapamycin operate. Previous work by ourselves and other groups exploring the structure-activity relationships (SAR) of small molecules that mimic only the FKBP binding domain portion of FK506 has focused on esters of proline and pipecolic acid. We have explored amide and thioester analogues of these earlier structures and found that they too are extremely potent in promoting recovery of lesioned dopaminergic pathways in a mouse model of Parkinson's disease. Several compounds were shown to be highly effective upon oral administration after lesioning of the dopaminergic pathway, providing further evidence of the potential clinical utility of a variety of structural classes of FKBP12 ligands.

Synthesis of meta,meta-Bridged Biaryls (-Metacyclophanes) via Aryl-Aryl Coupling: Factors affecting the Cyclisation

Two bis(iodoaryl)heptanoids (28) and (33), the iodoarylbutyl iodoarylpropyl sulphide (39), and the corresponding sulphone (40) have been prepared, and each treated with tetrakis(triphenylphosphine)nikel(0).Two new m,m-bridged biaryls (29) (31percent) and (34) (49percent) were obtained; the sulphur compounds were deiodinated in preference to coupling.These reactions are compared with those used previously in myricanol synthesis and the factors affecting ring closure are discussed.Steric effects at the coupling sites appear more important in determining product yield than torsional strain in the products.