885453-92-9Relevant academic research and scientific papers
Effect of C-ring modifications on the cytotoxicity of spirostan saponins and related glycosides
Pérez-Labrada, Karell,Brouard, Ignacio,Estévez, Sara,Marrero, María Teresa,Estévez, Francisco,Rivera, Daniel G.
experimental part, p. 4522 - 4531 (2012/09/05)
Twelve C-ring modified spirostanyl glycosides were synthesized and evaluated for their cytotoxicity against the human myeloid leukemia cell line (HL-60). With the aim of assessing the influence of the hydrophobic character, the conformational flexibility
Antifungal activity of 2α,3β-functionalized steroids stereoselectively increases with the addition of oligosaccharides
Cammarata, Amy,Upadhyay, Sunil Kumar,Jursic, Branko S.,Neumann, Donna M.
, p. 7379 - 7386 (2012/02/13)
Invasive fungal infections pose a significant problem to the immune-compromised. Moreover, increased resistance to common antifungals requires development of novel compounds that can be used to treat invasive fungal infections. Naturally occurring steroid
Synthesis of the cytotoxic gitogenin 3β-O-[2-O-(α-L- rhamnopyranosyl)-β-D-galactopyranoside] and its congeners
Li, Yingxia,Zhang, Yichun,Guo, Tiantian,Guan, Huashi,Hao, Yan,Yu, Biao
, p. 775 - 782 (2007/10/03)
(25R)-5a-Spirostan-2a,3b-diol (gitogenin) 3β-O-[2-O-(α-L- rhamnopyranosyl)-β-D-galactopyranoside] (1), a cytotoxic spirostan saponin isolated from the underground parts of Hosta longipes (Liliaceae), was concisely synthesized. In this context, its congeners 2-4 were also prepared. All four compounds showed comparable potency to dioscin in inhibition against the growth of tumor cells. Georg Thieme Verlag Stuttgart.
