885498-60-2Relevant academic research and scientific papers
PHOTOCHEMICAL PROCESS FOR THE FLUORTNATION OF AN ORGANIC COMPOUND HAVING AN UNACTIVATED SP3 C-H BOND
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Paragraph 0078, (2015/01/16)
The application provides a photochemical process for the chemoselective fluorination of an organic compound by combining a carbon-containing compound having an unactivated sp3 C-H bond with a reagent system comprised of a fluorinating agent, and a photocatalyst, in the presence of a light source. Provided as fluorinating agent is N-fluorobenzenesulfonimide (NFSI) or 1-chloromethy1-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor), as photocatalyst is tetrabutylammonium decatungstate (TBADT), and as light source is a 365 nm UV lamp. The reactions conditions result in the C-H bond being replaced by a C-F bond, to provide a fluorinated carbon-containing compound.
PROCESS FOR PREPARING FLUOROLEUCINE ALKYL ESTERS
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Page/Page column 8; 9, (2013/10/21)
This invention relates to a resolution process for the preparation of fluoroleucine alkyl esters.
A concise synthesis of (S)-γ-fluoroleucine ethyl ester
Nadeau, Christian,Gosselin, Francis,O'Shea, Paul D.,Davies, Ian W.,Volante, Ralph P.
, p. 291 - 295 (2007/10/03)
We report herein a six-step, chromatography-free, through-process for the asymmetric synthesis of (S)-γ-fluoroleucine ethyl ester sulfate salt (6) that proceeds in 25% overall yield from inexpensive ethyl glyoxylate. This approach features a Ti/Zn-catalyz
An efficient chemoenzymatic approach to (S)-γ-fluoroleucine ethyl ester
Limanto, John,Shafiee, Ali,Devine, Paul N.,Upadhyay, Veena,Desmond, Richard A.,Foster, Bruce R.,Gauthier Jr., Donald R.,Reamer, Robert A.,Volante
, p. 2372 - 2375 (2007/10/03)
(Chemical Equation Presented) An asymmetric synthesis of (S)-γ-fluoroleucine ethyl ester 1 is described. The key transformation involves a lipase-catalyzed dynamic ring-opening of 2-(3-butenyl)azlactone 7b with EtOH to give amide ester (S)-6b in 84% enant
