88550-30-5Relevant academic research and scientific papers
A stereoselective synthetic approach to N-alkyl-4β-methyl-5- phenylmorphans
Thomas, James B.,Gigstad, Kenneth M.,Fix, Scott E.,Burgess, Jason P.,Cooper, Julie B.,Mascarella, S. Wayne,Cantrell, Buddy E.,Zimmerman, Dennis M.,Carroll, F. Ivy
, p. 403 - 406 (1999)
A convergent, highly stereoselective synthetic approach to N-alkyl-4β- methyl-5-phenylmorphans has been developed utilizing alkylation of the metalloenamine of N-alkyl-1,2,3,6-tetrahydro-4-phenylpyridines with 2- (chloromethyl)-3,5-dioxahex-1-ene (Okahara's reagent) followed by Clemmensen reduction.
Racemic and Optically Active 2,9-Dimethyl-5-(m-hydroxyphenyl)morphans and Pharmacological Comparison with the 9-Demethyl Homologues
Awaya, Hiroyoshi,May, Everette L.,Aceto, Mario D.,Merz, Herbert,Rogers, Michael E.,Harris, Louis S.
, p. 536 - 539 (2007/10/02)
2,9α-Dimethyl-5-(m-hydroxyphenyl)morphan (3a) has been synthesized from 5-(m-methoxyphenyl)-2-methyl-9-oxomorphan (4) and resolved into its enantiomers (+)-3a and (-)-3a.The assigned α-orientation of the 9-methyl group was derived from studies of induced
