885523-41-1

Basic information

• Product Name: 1-BOC-4-ETHYL-4-FORMYL-PIPERIDINE
• Synonyms: 1-BOC-4-ETHYL-4-FORMYL-PIPERIDINE
• CAS NO: 885523-41-1
• Molecular Formula: C13H23NO3
• Molecular Weight: 241.33
• Mol File: 885523-41-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BOC-4-ETHYL-4-FORMYL-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-ETHYL-4-FORMYL-PIPERIDINE(885523-41-1)
• EPA Substance Registry System: 1-BOC-4-ETHYL-4-FORMYL-PIPERIDINE(885523-41-1)

Safety Data

• Hazardous Substances Data: 885523-41-1(Hazardous Substances Data)

Usage

Chemical class

Piperidine derivative

Functional groups

a. BOC (tert-butyloxycarbonyl) protecting group
b. Ethyl substituent
c. Formyl group

Structure

The formyl group and ethyl substituent are attached to the 4-position of the piperidine ring, while the BOC protecting group is attached to the 1-position.

Applications

a. Building block in organic synthesis
b. Preparation of pharmaceuticals and fine chemicals
c. Key intermediate in the production of agrochemicals and specialty chemicals

Role of BOC protecting group

a. Protects amines during organic synthesis
b. Facilitates selective reactions
c. Enhances the compound's value in chemical and pharmaceutical research and development.

Upstream product

• 188792-67-8 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid 
• 188792-70-3 ethyl 1-boc-4-ethyl-4-piperidine carboxylate 
• 578021-55-3 1-tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 

Relevant articles and documents

Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity

We discovered a novel compound, 5-methyl-1,4,5,7-tetrahydro-2,5-ethanoazocino[4,3-b]indol-6(3H)-one sulfuric acid salt (DS39201083), which was formed by derivatization of a natural product, conolidine. DS39201083 had a unique bicyclic skeleton and was a m

Muscarinic M3 receptor antagonists with (2R)-2-[(1R)-3,3-Difluorocyclopentyl]-2-hydroxyphenylacetamide Structures. Part 2

Optimization of the amine part of our original muscarinic M3 receptor antagonist 1 was performed to identify M3 receptor antagonists that are superior to 1. Compounds carrying a variety of diamine moieties without hydrophobic substituent on the nitrogen atom were screened against the binding affinity for the M3 receptor and the selectivity for M3 over the M1 and M2 receptors. This process led to a 4-aminopiperidinamide (2l) with a Ki value of 5.1 nM and with a selectivity of the M3 receptor that was 46-fold greater than that of the M2 receptor. Further derivatization of 2l by inserting a spacer group or by incorporating alkyl group(s) into the amine part resulted in the identification of an 4-(aminoethyl)piperidinamide 2l-b with a Ki value of 3.7 nM for the M3 receptor and a selectivity for the M3 receptor that was 170-fold greater than that of the M2 receptor.