188792-70-3Relevant academic research and scientific papers
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
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Paragraph 0524, (2015/10/28)
Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.
Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors
Axford, Lorraine C.,Agarwal, Piyush K.,Anderson, Kelly H.,Andrau, Laura N.,Atherall, John,Barker, Stephanie,Bennett, James M.,Blair, Michael,Collins, Ian,Czaplewski, Lloyd G.,Davies, David T.,Gannon, Carlie T.,Kumar, Dushyant,Lancett, Paul,Logan, Alastair,Lunniss, Christopher J.,Mitchell, Dale R.,Offermann, Daniel A.,Palmer, James T.,Palmer, Nicholas,Pitt, Gary R.W.,Pommier, Stéphanie,Price, Daniel,Narasinga Rao,Saxena, Rashmi,Shukla, Tarun,Singh, Amit K.,Singh, Mahipal,Srivastava, Anil,Steele, Christopher,Stokes, Neil R.,Thomaides-Brears, Helena B.,Tyndall, Edward M.,Watson, David,Haydon, David J.
, p. 6598 - 6603 (2014/01/06)
The discovery and optimisation of a new class of benzothiazole small molecules that inhibit bacterial DNA gyrase and topoisomerase IV are described. Antibacterial properties have been demonstrated by activity against DNA gyrase ATPase and potent activity against Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes and Haemophilus influenzae. Further refinements to the scaffold designed to enhance drug-likeness included analogues bearing an α-substituent to the carboxylic acid group, resulting in excellent solubility and favourable pharmacokinetic properties.
LUPEOL-TYPE TRITERPENE DERIVATIVES AS ANTIVIRALS
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Page/Page column 33, (2011/02/18)
The invention relates to novel lupeol-type triterpene derivatives and related compounds, and pharmaceutical compositions useful for therapeutic treatment of viral diseases and particularly HIV mediated diseases.
MELANOCORTIN RECEPTOR MODULATORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS
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Page/Page column 59, (2010/06/11)
The present invention relates to novel melanocortin receptor modulators corresponding to the general formula (I) to compositions containing them, to the process for preparing them and to their use in pharmaceutical or cosmetic compositions.
Amide compounds and use of the same
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, (2008/06/13)
An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like, R5
