885672-69-5

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE is used as a building block in the pharmaceutical industry for the synthesis of various medications and biologically active molecules. Its unique structure allows for the creation of new compounds with potential therapeutic properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE serves as a valuable component in the development of novel drugs. Its versatility and reactivity make it a promising candidate for designing molecules with specific biological activities.
Used in Research and Development:
1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE is also utilized in the research and development of new materials and chemicals. Its properties and reactivity make it a valuable tool for exploring new chemical reactions and creating innovative compounds with potential applications in various industries.
Overall, 1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE is a versatile and valuable chemical compound with diverse applications in the pharmaceutical, medicinal chemistry, and research and development industries. Its unique structure and properties make it a promising building block for the creation of new compounds with potential therapeutic and practical applications.

Upstream product

• 1143534-29-5 tert-butyl 1-(4-chlorophenyl)-3-(dimethylamino)propylcarbamate 
• 1143534-27-3 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate 
• 68208-26-4 3-amino-3-(4-chlorophenyl)propan-1-ol 
• 886493-66-9 tert-butyl 1-(4-chlorophenyl)-3-hydroxypropylcarbamate 
• 19947-39-8 3-amino-3-(4-chlorophenyl)propionic acid 
• 16254-21-0 3-(dimethylamino)-1-(4-chlorobenzene)-1-propanol 
• 2138-38-7 1-(4-chlorophenyl)-3-dimethylamino-1-propanone 

Downstream Products

• 885673-16-5 N-[1-(4-chlorophenyl)-3-dimethylaminopropyl]-2-phenylacetamide 
• 885673-11-0 N-[1-(4-chloro-phenyl)-3-dimethylamino-propyl]-2-methoxy-2-phenyl-acetamide 
• 885673-51-8 1-[1-(4-chlorophenyl)-3-dimethylaminopropyl]-3-(4-phenylphenyl)-carbamide 
• 885672-81-1 N-[1-(4-chlorophenyl)-3-(dimethylamino)propyl]-4-phenylbenzamide 
• 885672-75-3 N-[1-(4-chlorophenyl)-3-dimethylamino-propyl]-2-methyl-benzamide 
• 885673-59-6 N-[1-(4-chlorophenyl)-3-dimethylaminopropyl]-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases

Wide-ranging exploration of analogues of an ATP-competitive pyrrolopyrimidine inhibitor of Akt led to the discovery of clinical candidate AZD5363, which showed increased potency, reduced hERG affinity, and higher selectivity against the closely related AGC kinase ROCK. This compound demonstrated good preclinical drug metabolism and pharmacokinetics (DMPK) properties and, after oral dosing, showed pharmacodynamic knockdown of phosphorylation of Akt and downstream biomarkers in vivo, and inhibition of tumor growth in a breast cancer xenograft model.

PYRROLO [2,3-D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS

The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I)

Novel potent and efficacious nonpeptidic urotensin II receptor agonists

Six different series of nonpeptidic urotensin II receptor agonists have been synthesized and evaluated for their agonistic activity in a cell-based assay (R-SAT). The compounds are ring-opened analogues of the isochromanone-based agonist AC-7954 with different functionalities constituting the linker between the two aromatic ring moieties. Several of the compounds are highly potent and efficacious, with N-[1-(4-chlorophenyl)-3-(dimethylamino)- propyl]-4-phenylbenzamide oxalate (5d) being the most potent. The pure enantiomers of 5d were obtained from the corresponding diastereomeric amides. It was shown by a combination of X-ray crystallography and chemical correlation that the activity resides in the S-enantiomer of 5d (pEC50 7.49).

UII-MODULATING COMPOUNDS AND THEIR USE

Disclosed herein are novel aromatic-containing compounds and methods for using various aromatic-containing compounds for treatment and prevention of diseases and disorders related to the Urotensin II receptor.