885672-69-5

Basic information

• Product Name: 1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE
• Synonyms: 1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE
• CAS NO: 885672-69-5
• Molecular Formula: C₁₁H₁₇ClN₂
• Molecular Weight: 212.71908
• Mol File: 885672-69-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE(885672-69-5)
• EPA Substance Registry System: 1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE(885672-69-5)

Safety Data

• Hazardous Substances Data: 885672-69-5(Hazardous Substances Data)

Usage

General Description

1-(4-chloro-phenyl)-N3,N3-dimethyl-propane-1,3-diamine is a chemical compound with the molecular formula C11H18ClN3. It is a diamine derivative, containing a chlorophenyl group and two N,N-dimethylpropyl substituents. 1-(4-CHLORO-PHENYL)-N3,N3-DIMETHYL-PROPANE-1,3-DIAMINE is commonly used in the synthesis of pharmaceuticals and organic compounds, particularly in the production of medications and biologically active molecules. It has applications in medicinal chemistry and drug development due to its potential as a building block for creating new compounds with therapeutic properties. Additionally, it may also be used in research and development of new materials and chemicals. Overall, 1-(4-chloro-phenyl)-N3,N3-dimethyl-propane-1,3-diamine is a versatile chemical with diverse applications in various fields.

Upstream product

• 2138-38-7 1-(4-chlorophenyl)-3-dimethylamino-1-propanone 
• 1143534-29-5 tert-butyl 1-(4-chlorophenyl)-3-(dimethylamino)propylcarbamate 
• 1143534-27-3 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate 
• 886493-66-9 tert-butyl 1-(4-chlorophenyl)-3-hydroxypropylcarbamate 
• 68208-26-4 3-amino-3-(4-chlorophenyl)propan-1-ol 
• 19947-39-8 3-amino-3-(4-chlorophenyl)propionic acid 
• 16254-21-0 3-(dimethylamino)-1-(4-chlorobenzene)-1-propanol 

Downstream Products

• 885673-51-8 1-[1-(4-chlorophenyl)-3-dimethylaminopropyl]-3-(4-phenylphenyl)-carbamide 
• 885672-81-1 N-[1-(4-chlorophenyl)-3-(dimethylamino)propyl]-4-phenylbenzamide 
• 885672-75-3 N-[1-(4-chlorophenyl)-3-dimethylamino-propyl]-2-methyl-benzamide 
• 885673-16-5 N-[1-(4-chlorophenyl)-3-dimethylaminopropyl]-2-phenylacetamide 

Relevant articles and documents

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases

Wide-ranging exploration of analogues of an ATP-competitive pyrrolopyrimidine inhibitor of Akt led to the discovery of clinical candidate AZD5363, which showed increased potency, reduced hERG affinity, and higher selectivity against the closely related AGC kinase ROCK. This compound demonstrated good preclinical drug metabolism and pharmacokinetics (DMPK) properties and, after oral dosing, showed pharmacodynamic knockdown of phosphorylation of Akt and downstream biomarkers in vivo, and inhibition of tumor growth in a breast cancer xenograft model.

Novel potent and efficacious nonpeptidic urotensin II receptor agonists

Six different series of nonpeptidic urotensin II receptor agonists have been synthesized and evaluated for their agonistic activity in a cell-based assay (R-SAT). The compounds are ring-opened analogues of the isochromanone-based agonist AC-7954 with different functionalities constituting the linker between the two aromatic ring moieties. Several of the compounds are highly potent and efficacious, with N-[1-(4-chlorophenyl)-3-(dimethylamino)- propyl]-4-phenylbenzamide oxalate (5d) being the most potent. The pure enantiomers of 5d were obtained from the corresponding diastereomeric amides. It was shown by a combination of X-ray crystallography and chemical correlation that the activity resides in the S-enantiomer of 5d (pEC50 7.49).