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Usage

Uses

Used in Pharmaceutical Industry:
3-(Boc-aMino)-3-(4-chlorophenyl)-1-propanol is used as an intermediate in the production of pharmaceuticals for its role in the synthesis of biologically active compounds. The Boc protecting group allows chemists to selectively modify the amino functionality, which is crucial for the development of new drugs with specific therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 3-(Boc-aMino)-3-(4-chlorophenyl)-1-propanol serves as a key intermediate. Its structural features, including the Boc protecting group and the chlorophenyl moiety, make it a versatile component in creating a wide range of complex organic molecules for various applications, including but not limited to materials science, agrochemicals, and specialty chemicals.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 68208-26-4 3-amino-3-(4-chlorophenyl)propan-1-ol 
• 19947-39-8 3-amino-3-(4-chlorophenyl)propionic acid 

Downstream Products

• 1143535-51-6 tert-butyl 1-(4-chlorophenyl)-3-methoxypropylcarbamate 
• 1143534-27-3 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propyl Methanesulfonate 
• 1143535-59-4 tert-butyl 1-(4-chlorophenyl)-3-sulfamoylpropylcarbamate 
• 1143535-61-8 3-amino-3-(4-chlorophenyl)propane-1-sulfonamide 
• 1143534-29-5 tert-butyl 1-(4-chlorophenyl)-3-(dimethylamino)propylcarbamate 
• 885672-69-5 1-(4-chlorophenyl)-N³,N³-dimethylpropane-1,3-diamine 
• 1143535-53-8 1-(4-chlorophenyl)-3-methoxypropan-1-amine 
• 1143532-43-7 4-amino-N-(1-(4-chlorophenyl)-3-(dimethylamino)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 
• 1143533-70-3 (S)-4-amino-N-(1-(4-chlorophenyl)-3-(dimethylamino)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 
• 1143533-52-1 4-amino-N-(1-(4-chlorophenyl)-3-sulfamoylpropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 
• 1143533-50-9 4-amino-N-(1-(4-chlorophenyl)-3-methoxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 

Relevant academic research and scientific papers

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases

Wide-ranging exploration of analogues of an ATP-competitive pyrrolopyrimidine inhibitor of Akt led to the discovery of clinical candidate AZD5363, which showed increased potency, reduced hERG affinity, and higher selectivity against the closely related AGC kinase ROCK. This compound demonstrated good preclinical drug metabolism and pharmacokinetics (DMPK) properties and, after oral dosing, showed pharmacodynamic knockdown of phosphorylation of Akt and downstream biomarkers in vivo, and inhibition of tumor growth in a breast cancer xenograft model.

PYRROLO [2,3-D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS

The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I)