885672-81-1

Basic information

• Product Name: [1,1'-Biphenyl]-4-carboxaMide, N-[1-(4-chlorophenyl)-3-(diMethylaMino)propyl]-
• Synonyms: [1,1'-Biphenyl]-4-carboxaMide, N-[1-(4-chlorophenyl)-3-(diMethylaMino)propyl]-;N-[1-(4-chlorophenyl)-3-(dimethylamino)propyl]-4-phenylbenzamide
• CAS NO: 885672-81-1
• Molecular Formula: C24H25ClN2O
• Molecular Weight: 392.9211
• Mol File: 885672-81-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [1,1'-Biphenyl]-4-carboxaMide, N-[1-(4-chlorophenyl)-3-(diMethylaMino)propyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-4-carboxaMide, N-[1-(4-chlorophenyl)-3-(diMethylaMino)propyl]-(885672-81-1)
• EPA Substance Registry System: [1,1'-Biphenyl]-4-carboxaMide, N-[1-(4-chlorophenyl)-3-(diMethylaMino)propyl]-(885672-81-1)

Safety Data

• Hazardous Substances Data: 885672-81-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
[1,1'-Biphenyl]-4-carboxamide, N-[1-(4-chlorophenyl)-3-(dimethylamino)propyl]is used as a pharmaceutical compound for its potential therapeutic properties. Its unique structure may allow it to interact with specific biological targets, making it a candidate for the development of new drugs.
Used in Materials Science:
In the field of materials science, [1,1'-Biphenyl]-4-carboxamide, N-[1-(4-chlorophenyl)-3-(dimethylamino)propyl]is used as a component in the development of new materials. Its structural characteristics may contribute to the creation of materials with specific properties, such as improved strength, flexibility, or chemical resistance.
Used in Chemical Research:
[1,1'-Biphenyl]-4-carboxamide, N-[1-(4-chlorophenyl)-3-(dimethylamino)propyl]is also used in chemical research as a subject for further study and analysis. Understanding its properties and reactivity can provide valuable insights into its potential applications and uses in various industries.

Upstream product

• 2138-38-7 1-(4-chlorophenyl)-3-dimethylamino-1-propanone 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 885673-11-0 N-[1-(4-chloro-phenyl)-3-dimethylamino-propyl]-2-methoxy-2-phenyl-acetamide 
• 92-92-2 biphenyl-4-carboxylic acid 
• 16254-21-0 3-(dimethylamino)-1-(4-chlorobenzene)-1-propanol 
• 885672-69-5 1-(4-chlorophenyl)-N³,N³-dimethylpropane-1,3-diamine 

Relevant articles and documents

Novel and potent small-molecule urotensin II receptor agonists

A series of analogs of the non-peptidic urotensin II receptor agonist N-[1-(4-chlorophenyl)-3-(dimethylamino)propyl]-4-phenylbenzamide (FL104) has been synthesized and evaluated pharmacologically. The enantiomers of the two most potent racemic analogues were obtained from the corresponding diastereomeric mandelic amides. In agreement with previously observed SAR, most of the agonist potency resided in the (S) enantiomers. The most potent UII receptor agonist in the new series was (S)-N-[3-dimethylamino-1-(2-naphthyl)propyl]-4-(4-chlorophenyl)benzamide (EC50 = 23 nM at the urotensin II receptor).

UII-MODULATING COMPOUNDS AND THEIR USE

Disclosed herein are novel aromatic-containing compounds and methods for using various aromatic-containing compounds for treatment and prevention of diseases and disorders related to the Urotensin II receptor.

UII-MODULATING COMPOUNDS AND THEIR USE

Disclosed herein are novel aromatic-containing compounds and methods for using various aromatic-containing compounds for treatment and prevention of diseases and disorders related to the Urotensin II receptor.

Novel potent and efficacious nonpeptidic urotensin II receptor agonists

Six different series of nonpeptidic urotensin II receptor agonists have been synthesized and evaluated for their agonistic activity in a cell-based assay (R-SAT). The compounds are ring-opened analogues of the isochromanone-based agonist AC-7954 with different functionalities constituting the linker between the two aromatic ring moieties. Several of the compounds are highly potent and efficacious, with N-[1-(4-chlorophenyl)-3-(dimethylamino)- propyl]-4-phenylbenzamide oxalate (5d) being the most potent. The pure enantiomers of 5d were obtained from the corresponding diastereomeric amides. It was shown by a combination of X-ray crystallography and chemical correlation that the activity resides in the S-enantiomer of 5d (pEC50 7.49).