886-29-3

Basic information

• Product Name: 2-[(3-nitrophenyl)carbonyl]hydrazinecarbothioamide
• CAS NO: 886-29-3
• Molecular Formula: C₈H₈N₄O₃S
• Molecular Weight: 240.2391
• Mol File: 886-29-3.mol
• Article Data: 3

Chemical Properties

• Density: 1.509g/cm³
• Refractive Index: 1.69
• CAS DataBase Reference: 2-[(3-nitrophenyl)carbonyl]hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3-nitrophenyl)carbonyl]hydrazinecarbothioamide(886-29-3)
• EPA Substance Registry System: 2-[(3-nitrophenyl)carbonyl]hydrazinecarbothioamide(886-29-3)

Safety Data

• Hazardous Substances Data: 886-29-3(Hazardous Substances Data)

Usage

General Description

2-[(3-nitrophenyl)carbonyl]hydrazinecarbothioamide is a chemical compound with the molecular formula C8H7N5O3S. It is a derivative of hydrazinecarbothioamide and contains a nitrophenylcarbonyl group. 2-[(3-nitrophenyl)carbonyl]hydrazinecarbothioamide is a hydrazine-based thioamide and has potential applications in organic synthesis and medicinal chemistry. It may also have biological activities that make it a potential candidate for drug discovery and development. Its chemical structure and functional groups suggest that it could interact with biological targets, making it of interest for further research and investigation.

Upstream product

• 121-92-6 3-nitrobenzoic acid 
• 79-19-6 thiosemicarbazide 
• 121-90-4 m-nitrobenzoic acid chloride 
• 333-20-0 potassium thioacyanate 
• 618-94-0 3-nitrobenzoic acid hydrazide 

Downstream Products

• 864-34-6 N-{4-[5-(3-nitro-phenyl)-[1,3,4]thiadiazol-2-ylsulfamoyl]-phenyl}-phthalamic acid 
• 988-68-1 N-{4-[5-(3-nitro-phenyl)-[1,3,4]thiadiazol-2-ylsulfamoyl]-phenyl}-succinamic acid 
• 1055-95-4 4-acetylamino-N-[5-(3-nitro-phenyl)-[1,3,4]thiadiazol-2-yl]-benzenesulfonamide 
• 856-26-8 4-amino-N-[5-(3-nitro-phenyl)-[1,3,4]thiadiazol-2-yl]-benzenesulfonamide 
• 344319-56-8 2-[(E)-Hydroxyimino]-N-[5-(3-nitro-phenyl)-[1,3,4]thiadiazol-2-yl]-acetamide 
• 259243-24-8 2-(3-nitrophenyl)-6-benzylidenethiazolo[3,2:b]-1,2,4-triazol-5(6H)-one 
• 6219-47-2 5-(3-nitro-phenyl)-2,4-dihydro-[1,2,4]triazole-3-thione 
• 833-47-6 5-(3-nitrophenyl)-1,3,4-thiadiazol-2-amine 
• 50566-89-7 3-nitro-benzoic acid N'-(4-amino-5-phenyl-thiazol-2-yl)-hydrazide 

Relevant articles and documents

Novel panaxadiol triazole derivatives induce apoptosis in HepG-2 cells through the mitochondrial pathway

In this study, we introduced 1, 2, 4-triazole groups into panaxadiol (PD) to obtain 18 panaxadiol triazole derivatives. Five cancer cells and one normal cell were evaluated for cytotoxicity by MTT assay. The results showed that most of the derivatives could inhibit cancer cell proliferation, and the anti-proliferative activity of compound A1 was the most significant. For HepG-2 cells, the IC50 value was 4.21 ± 0.54 μM, which was nearly 15 times higher than the activity of PD. Further studies showed that compound A1 could induce apoptosis in HepG-2 cells, and could enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Moreover, Western blot analysis showed that after treating HepG-2 cells with compound A1, the expression of p53 protein was increased and the ratio of Bax/Bcl-2 was gradually increased. The cytoplasmic Bax is then translocated to the mitochondria, causing the release of Cyt c protein. Therefore, the results indicate that compound A1 induces apoptosis through the mitochondrial pathway and can be used the potential to develop new anti-proliferative agents.

Synthesis and evaluation of anti-inflammatory activity of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their Michael addition products

Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones (4-10) were obtained in a one step synthesis by heating 3-aryl-5-mercapto-1,2,4-triazoles (3a-d) with chloroacetic acid and appropriate aromatic aldehyde in acetic acid and acetic anhydride in the presence of anhydrous NaOAc. Michael type addition of cyclic secondary amines (N-methylpiperazine, piperidine) to 4-10 gave 2-phenyl-6- (α-aminoarylmethyl)thiazolo[3,2-b]-1,2,4-triazole-5-ols (4a-10b). The structures of the compounds were confirmed by spectral and elementary analysis. The compounds synthesized in previous and present studies were investigated for their anti-inflammatory activities.