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Axitinib
Cas No: 319460-85-0
No Data 10 Gram 10 Kilogram/Month Jinan Xinke Pharmaceutical Science and Technology Co., Ltd. Contact Supplier
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Cas No: 319460-85-0
USD $ 160.0-160.0 / Gram 5 Gram 100 Kilogram/Month Beijing Mesochem Technology Co.,LTD Contact Supplier
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No Data No Data No Data Hangzhou Hysen Pharma co.,Ltd. Contact Supplier
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Cas No: 319460-85-0
No Data No Data No Data Suzhou Candor Chemical Technology Co.,Ltd. Contact Supplier
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Cas No: 319460-85-0
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High purity Various Specifications Axitinib CAS:319460-85-0
Cas No: 319460-85-0
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
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No Data 1 Gram 100 Metric Ton/Month Yurui(Shanghai)Chemical Co.,Ltd Contact Supplier
High quality Axitinib supplier in China
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No Data No Data No Data Simagchem Corporation Contact Supplier
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319460-85-0 Usage

Definition

ChEBI: An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic tr atment.

Uses

Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Uses

A tyrosine kinase inhibitor; used in cancer therapy.

FDA approved axitinib use of treating advanced kidney cancer

January 27, 2012, the FDA approved axitinib for the treatment of advanced kidney cancer (renal cell carcinoma) which other drugs unanswer . Inlyta is manufactured and sold by Pfizer,and is a oral pill taken twice a day.
Renal cell carcinoma is a type of tumor originating from the tubular endothelial cells. Axitinib can prevent certain protein called kinases playing a role in tumor growth and metastasis .
Axitinib is a small molecule tyrosine kinase inhibitor, effective against multiple targets, including VEGF receptors 1, 2 and 3.
Dr. Richard Pazdur, hematology and oncology drugs office director of FDA Drug Evaluation and Research Centre, said: "This is the seven kind of drugs allowed treating metastatic or advanced renal cell carcinoma since 2005 . Overall, during this time ,record level of drug development has dramatically changed the treatment of metastatic renal cell carcinoma paradigm, and offers a variety of treatment options for patients. "
In recent years, the drug has been approved for the treatment of kidney cancer include sorafenib (2005), sunitinib (2006), temsirolimus(2007), everolimus (2009), bevacizumab(2009) and pazopanib(2009).
The above information is edited by the chemicalbook of Tian Ye.

Uses

Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.

Chemical Properties

Off-White Solid

Uses

Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.
InChI:InChI=1/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

319460-85-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (PZ0193)  Axitinib  ≥98% (HPLC) 319460-85-0 PZ0193-5MG 1,126.71CNY Detail

319460-85-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name axitinib

1.2 Other means of identification

Product number -
Other names AG-013736 N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:319460-85-0 SDS

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