88627-14-9Relevant academic research and scientific papers
Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists
Negoro, Kenji,Yonetoku, Yasuhiro,Maruyama, Tatsuya,Yoshida, Shigeru,Takeuchi, Makoto,Ohta, Mitsuaki
, p. 2369 - 2375 (2012/05/05)
Through preparation and examination of a series of novel 4-amino-2-phenylpyrimidine derivatives as agonists for GPR119, we identified 2-(4-bromophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (9t). Compound 9t improved glucose tolerance in mice following oral administration and showed good pharmacokinetic profiles in rats.
Reaction of Aryl-Substituted Azidopyrimidines with 1,3-Dicarbonyl Compounds
Krivopalov, V. P.,Nikolaenkova, E. B.,Sedova, V. F.,Mamaev, V. P.
, p. 1116 - 1119 (2007/10/02)
Substituted 1-pyrimidyl-4-acyl-1,2,3-triazoles were obtained by the reaction of 2- and 4-azidopyrimidines with aryl substituents with acetyl- or benzoylacetone.An accelerating effect of an o-hydroxyphenylpyrimidine fragment in this reaction, which was explained by the effect of an intramolecular hydrogen bond, was observed.
