88636-66-2

Upstream product

• 186581-53-3 diazomethane 
• 41864-05-5 2-cyano-2-methyl-3-phenylpropanoic acid 
• 57519-78-5 methyl 2-cyano-4-phenylpropanoate 
• 74-88-4 methyl iodide 

Downstream Products

• 41864-05-5 2-cyano-2-methyl-3-phenylpropanoic acid 
• 61137-36-8 (S)-4-benzyl-4-methyloxazolidin-2,5-dione 
• 159835-31-1 (R)-α-benzyl-α-methylmalonamic acid 
• 1027072-52-1 (S)-2-Cyano-2-methyl-3-phenyl-propionyl azide 
• 108211-28-5 (R)-(-)-2-cyano-2-methyl-3-phenylpropionic acid 
• 27771-05-7 (S)-(+)-2-cyano-2-methyl-3-phenylpropanoic acid 
• 23239-35-2 (S)-2-amino-2-methyl-3-phenylpropanoic acid 
• 27809-87-6 (+/-)-2-Benzyl-3-hydroxy-2.3-dimethylbutyronitril 

Relevant academic research and scientific papers

Efficient resolution of rac-2-cyano-2-methyl-3-phenylpropanoic acid. An appropriate starting material for the enantioconvergent synthesis of (S)-α-methylphenylalanine on a large laboratory scale

A large laboratory scale synthesis of (S)-α-methylphenylalanine from benzaldehyde and methyl cyanoacetate has been developed. The synthesis is based on the following sequence: (i) preparation of racemic 2-cyano-2-methyl-3-phenylpropanoic acid, (ii) resolu