108211-28-5

Basic information

• Product Name: (R)-(-)-2-cyano-2-methyl-3-phenylpropionic acid
• Synonyms: (R)-(-)-2-cyano-2-methyl-3-phenylpropionic acid
• CAS NO: 108211-28-5
• Molecular Weight: 189.214
• Mol File: 108211-28-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (R)-(-)-2-cyano-2-methyl-3-phenylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-2-cyano-2-methyl-3-phenylpropionic acid(108211-28-5)
• EPA Substance Registry System: (R)-(-)-2-cyano-2-methyl-3-phenylpropionic acid(108211-28-5)

Safety Data

• Hazardous Substances Data: 108211-28-5(Hazardous Substances Data)

Upstream product

• 41864-05-5 2-cyano-2-methyl-3-phenylpropanoic acid 
• 108138-99-4 (R)-2-Benzyl-3-((2R,5R)-2,5-bis-methoxymethoxymethyl-pyrrolidin-1-yl)-2-methyl-3-oxo-propionitrile 
• 143100-04-3 (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2-methyl-3-phenylpropanoate 
• 132640-95-0 (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl (E)-2-cyanocinnamate 
• 74-88-4 methyl iodide 
• 21455-96-9 α-benzyl-α-methylmalononitrile 
• 507275-33-4 (R)-2-cyano-2-methyl-3-phenylpropionic acid ethyl ester 
• 526221-34-1 (R)-2-hydroxymethyl-2-methyl-3-phenylpropionitrile 
• 57519-78-5 methyl 2-cyano-4-phenylpropanoate 
• 88636-66-2 methyl 2-cyano-2-methyl-3-phenylpropanoate 
• 1867-37-4 Benzylmalononitrile 
• 100-39-0 benzyl bromide 
• 159835-31-1 (R)-α-benzyl-α-methylmalonamic acid 
• 1572-95-8 (R)-1-phenyl-propan-2-ol 

Downstream Products

• 507275-34-5 (R)-2-methoxycarbonylamino-2-methyl-3-phenylpropanonitrile 
• 159835-31-1 (R)-α-benzyl-α-methylmalonamic acid 
• 607720-66-1 methyl (R)-2-cyano-2-methyl-3-phenylpropanoate 
• 33802-51-6 α-methyl-β-phenylpropionitrile 
• 607720-65-0 (S)-2-benzyl-3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-2-methylpropionitrile 
• 607720-62-7 (R)-2-mesyloxymethyl-2-methyl-3-phenylpropionitrile 
• 61137-36-8 (S)-4-benzyl-4-methyloxazolidin-2,5-dione 
• 607720-63-8 (S)-3-azido-2-benzyl-2-methylpropionitrile 
• 607720-64-9 (S)-3-amino-2-benzyl-2-methylpropionitrile 
• 526221-34-1 (R)-2-hydroxymethyl-2-methyl-3-phenylpropionitrile 
• 23239-35-2 (S)-2-amino-2-methyl-3-phenylpropanoic acid 

Relevant articles and documents

Synthesis of (R)- and (S)-3-benzyl-3-methyl-2-azetidinone in enantiomerically pure form

The diastereoselective methylation of the enolate of 10-dicyclohexylsulfamoylisobornyl-3-phenyl-2-cyanopropanoate is reported. This methylation was carried out under a variety of conditions to achieve a good yield and selectivity and the reaction product

Stereospecific construction of chiral quaternary carbon compounds from chiral secondary alcohol derivatives

Chiral tertiary dichloromethylcarbinol derivatives, prepared by stereospecific α C-H insertion reaction of dichlorocarbene with protected chiral secondary alcohols, were converted into intermediary α-chloroepoxides which gave stereospecifically chiral qua

Efficient resolution of rac-2-cyano-2-methyl-3-phenylpropanoic acid. An appropriate starting material for the enantioconvergent synthesis of (S)-α-methylphenylalanine on a large laboratory scale

A large laboratory scale synthesis of (S)-α-methylphenylalanine from benzaldehyde and methyl cyanoacetate has been developed. The synthesis is based on the following sequence: (i) preparation of racemic 2-cyano-2-methyl-3-phenylpropanoic acid, (ii) resolu