886364-47-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(6-BROMO-PYRIDIN-3-YL)-2,2,2-TRIFLUORO-ETHANONE is used as a building block for the production of various pharmaceuticals due to its ability to be incorporated into the molecular structures of different drugs. Its presence in these compounds can contribute to the development of new medications with specific therapeutic properties.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 1-(6-BROMO-PYRIDIN-3-YL)-2,2,2-TRIFLUORO-ETHANONE serves as a key component in the synthesis of agrochemicals, potentially enhancing the effectiveness of pesticides, herbicides, and other agricultural products.
Used as a Reagent in Organic Synthesis:
1-(6-BROMO-PYRIDIN-3-YL)-2,2,2-TRIFLUORO-ETHANONE is also utilized as a reagent in organic synthesis, where it can participate in various chemical reactions to form a wide range of organic compounds. Its versatility in organic chemistry makes it a useful tool for researchers and chemists in the development of new chemical entities.
Used for Exploring Potential Biological Activities:
Given its potential biological activities, 1-(6-BROMO-PYRIDIN-3-YL)-2,2,2-TRIFLUORO-ETHANONE is used in research to explore its effects on biological systems. This can lead to the discovery of new applications in medicine and other fields where understanding the compound's interactions with biological molecules is crucial.

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 360-95-2 2,2,2-Trifluoro-1-morpholin-4-yl-ethanone 
• 1188477-81-7 1-(6-bromopyridin-3-yl)-2,2,2-trifluoroethanol 
• 149806-06-4 6-bromonicotinaldehyde 
• 26218-78-0 methyl 6-bromonicotinate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 1188477-89-5 1-(6-cyanopyridin-3-yl)-2,2,2-trifluoroethyl 4-methylbenzenesulfonate 
• 1188477-81-7 1-(6-bromopyridin-3-yl)-2,2,2-trifluoroethanol 
• 1450620-92-4 benzyl (3S)-4-(5-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate 

Relevant academic research and scientific papers

NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1

An object of the invention is to provide compounds as selective JAK1 inhibitor, a process for preparation of the inhibitors, a composition containing the compounds and utility of the compounds.

SPIROCYCLIC ROR-GAMMA MODULATORS

Described herein are retinoic acid related-related orphan nuclear receptor (ROR) modulators and methods of utilizing ROR-gamma modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

BICYCLIC ROR-GAMMA MODULATORS

Described herein are retinoic acid related-related orphan nuclear receptor (ROR) modulators and methods of utilizing ROR-gamma modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N′-arylpiperazine series

We have recently reported a novel approach to increase cytosolic glucokinase (GK) levels through the binding of a small molecule to its endogenous inhibitor, glucokinase regulatory protein (GKRP) these initial investigations culminated in the identification of 2-(4-((2S)-4-((6-amino-3- pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3, 3-hexafluoro-2-propanol (1, AMG-3969), a compound that effectively enhanced GK translocation and reduced blood glucose levels in diabetic animals. Herein we report the results of our expanded SAR investigations that focused on modifications to the aryl carbinol group of this series. Guided by the X-ray cocrystal structure of compound 1 bound to hGKRP, we identified several potent GK-GKRP disruptors bearing a diverse set of functionalities in the aryl carbinol region. Among them, sulfoximine and pyridinyl derivatives 24 and 29 possessed excellent potency as well as favorable PK properties. When dosed orally in db/db mice, both compounds significantly lowered fed blood glucose levels (up to 58%).

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)

A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then oxidized conveniently and efficiently by o-iodoxybenzoic acid (IBX) under mild conditions to get the desired functionalized aryl and heteroaryl trifluoromethyl ketones.

SULFONYL COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

The present invention relates to sulfonyl compounds that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.