886364-50-7

Basic information

• Product Name: 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone
• Synonyms: 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone
• CAS NO: 886364-50-7
• Molecular Formula: C7H3BrF3NO
• Molecular Weight: 254
• Mol File: 886364-50-7.mol

Chemical Properties

• Boiling Point: 236℃
• Flash Point: 97℃
• Appearance: /
• Density: 1.730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.40±0.10(Predicted)
• CAS DataBase Reference: 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone(886364-50-7)
• EPA Substance Registry System: 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone(886364-50-7)

Safety Data

• Hazardous Substances Data: 886364-50-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone is used as a key intermediate in organic synthesis for its ability to engage in multiple types of chemical reactions, facilitating the creation of a wide array of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone is utilized as a building block in the development of new drugs and pharmaceutical products, capitalizing on its reactivity and biological activity.
Used in Antimicrobial and Antifungal Agents:
1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone is employed as an antimicrobial and antifungal agent due to its inherent properties that help combat various microorganisms, contributing to the development of treatments for infectious diseases.
Safety Considerations:
Given its high reactivity and potential health hazards, 1-(5-Bromo-2-pyridinyl)-2,2,2-trifluoroethanone should be handled with extreme caution. It is imperative to follow proper safety protocols during its use to mitigate risks associated with exposure.

Upstream product

• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 
• 31181-90-5 5-bromo-pyridine-2-carbaldehyde 
• 917397-92-3 1-(5-bromo-pyridin-2-yl)-2,2,2-trifluoroethanol 
• 624-28-2 2,5-dibromopyridine 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 917397-92-3 1-(5-bromo-pyridin-2-yl)-2,2,2-trifluoroethanol 
• 1454907-29-9 benzyl[1-(5-bromopyridin-2-yl)-2,2,2-trifluoroethyl]amine 
• 1454907-30-2 1-((4R,5R)-5-{4-[6-(1-benzylamino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone 
• 1454907-31-3 1-((4R,5R)-5-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone 
• 1454904-56-3 N-((1S,2R)-2-{4-[6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-difluoroacetamide 
• 1454907-33-5 2,2-difluoro-1-((4S,5R)-4-fluoromethyl-2,2-dimethyl-5-{4-[6-(2,2,2-trifluoro-1-methylaminoethyl)pyridin-3-yl]phenyl}oxazolidin-3-yl)ethanone 
• 1454904-57-4 2,2-difluoro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[6-(2,2,2-trifluoro-1-methylaminoethyl)pyridin-3-yl]phenyl}ethyl)acetamide 
• 1454907-28-8 benzyl-[1-(5-brompyridin-2-yl)-2,2,2-trifluoroeth-(E)-ylidene]amine 

Relevant articles and documents

PHENICOL ANTIBACTERIALS

The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)

A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then oxidized conveniently and efficiently by o-iodoxybenzoic acid (IBX) under mild conditions to get the desired functionalized aryl and heteroaryl trifluoromethyl ketones.

REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B

The instant invention relates to compounds of formula I, diagrammed below, wherein R3, E, D and Y are defined in the application, which are useful as reversible inhibitors of monoamine oxidase-B and/or monoamine oxidase-A, and therefore useful to treat or prevent neurological diseases or conditions in mammals, preferably humans.