886366-28-5Relevant academic research and scientific papers
Introducing a potential lead structure for the synthesis of more specific inhibitors of tyrosinases and catechol oxidases
Amirzakaria, Javad Zamani,Eshghi, Hossein,Ghorbanian, Nargess,Haghbeen, Faheimeh,Haghbeen, Kamahldin,Hajatpour, Golnaz
, (2021/09/22)
Based on tyrosinase inhibition science, two pyrimidine derivatives were designed and studied. Docking of 2-dibenzylamine-5-hydroxy pyrimidine (dba5HP) and 2-benzylamino-5-hydroxy pyrimidine (ba5HP) on mushroom tyrosinase (MT) showed that the former could not occupy MT active site pocket, while ba5HP could do so (Moldock score = ? 63.95). MD simulation revealed that the complex of ba5HP-MT reached stability 50 = 32.28, Ki = 11.32?μM). Considering the facile synthesis, potential for structural modifications, and passing most of the lead-likeness filters, it seems likely that ba5HP plays key roles in the syntheses of novel depigmentation medicines as well as more specific inhibitors for various tyrosinases and polyphenol oxidases.
Synthesis of pyridine, pyrimidine and pyridinone C-nucleoside phosphoramidites for probing cytosine function in RNA
Lu, Jun,Li, Nan-Sheng,Koo, Selene C.,Piccirilli, Joseph A.
experimental part, p. 8021 - 8030 (2010/02/17)
(Chemical Equation Presented) In the structures of the HDV ribozyme a cytosine nucleobase resides at the active site poised to participate directly in catalysis. Defining the functional role of the nucleobase requires nucleoside analogues that perturb the
