886370-56-5

Upstream product

• 637014-30-3 (3R,4R)-3-benzyl-4-hydroxymethylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 637014-20-1 (3R,4R,1'R)-3-benzyl-4-benzyloxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one 
• 637014-26-7 (3R,4R,1'R)-3-benzyl-4-benzyloxymethyl-1-(1'-phenylethyl)-pyrrolidine 
• 637014-18-7 (4R,1'R)-4-benzyloxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one 
• 190957-22-3 (4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one 

Downstream Products

• 895240-04-7 (3S,4S)-3-benzyl-4-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 637014-30-3 (3R,4R)-3-benzyl-4-hydroxymethylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 637014-31-4 methyl (3R,4R,)-4-benzyl-1-t-butoxycarbonyl-3-pyrrolidinecarboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS FOR MODULATING NR2F6

The present disclosure relates to compounds capable of modulating the activity of NR2F6. The compounds of the disclosure may be used in methods for the prevention and/or the treatment of diseases and disorders associated with modulating NR2F6 activity.

PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS

Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on the activity of b

ORGANIC COMPOUNDS

Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel inter-mediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula (I), wherein the substituents are as described in the specificacion.

A stereoselective approach to both 3,4-trans-disubstituted pyrrolidin-2-ones and pyrrolidines. A convenient synthesis of (3R,4R)-4-benzyl-3-pyrrolidinecarboxylic acid

Chiral 4-alkyloxymethyl- and silyloxymethylpyrrolidin-2-ones, (10a-c), underwent alkylation to give the corresponding 3,4-trans-disubstituted pyrrolidin-2-ones, (11a-g), in good yield and total stereoselection, as shown by 1H NMR spectral data