88643-73-6

Upstream product

• 52574-63-7 (5S,11S,13aR)-5-Benzyl-8,8-dimethyl-11-(6-oxo-oct-7-enyl)-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone 
• 89760-54-3 1-{2-[2-(2-tert-Butoxycarbonylamino-dec-9-enoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 
• 89760-48-5 Boc-DL-Ade-Aib-L-Phe-D-Pro-OMe 
• 89760-52-1 cyclo-(L-Ade-Aib-L-Phe-D-Pro) 
• 88568-94-9 (5S,11S,13aR)-5-Benzyl-11-{5-[2-(2-chloro-ethyl)-[1,3]dioxolan-2-yl]-pentyl}-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone 
• 52574-64-8 Dihydrochlamydocin 
• 52574-64-8 (5S,11S,13aR)-5-Benzyl-11-((R)-6-hydroxy-6-(S)-oxiranyl-hexyl)-8,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone 
• 89278-34-2 8-Benzyloxy-6(S),7(S)-O-isopropylidene-1-octanal 
• 89278-30-8 (E/Z)-8-Benzyloxy-6(S),7(S)-O-isopropylidene-4-octenal 
• 108071-96-1 Methyl 2(S)-benzyloxycarbonylamino-10-hydroxy-8(S),9(S)-O-isopropylidenedecanoate 
• 89278-33-1 cyclo-<(2(S)-Amino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl)-dimethylglycyl-(S)-phenylalanyl-(R)-prolyl> 
• 108071-98-3 Methyl of N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate 
• 89321-01-7 Pentafluorophenyl N-<2(S)-benzyloxycarbonylamino-10-chloro-8(S),9(R)-O-isopropylidenedecanoyl>-dimethylglycyl-(S)-phenylalanyl-(R)-prolinate 
• 89278-31-9 Methyl 10-Benzyloxy-2-(S)-benzyloxycarbonylamino-8(S),9(S)-O-isopropylidene-2(E/Z),6(E/Z)-decadienoate 

Relevant academic research and scientific papers

Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via a Late-Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin

A unified step-economical strategy for accessing histone deacetylase inhibitory peptides is proposed, based on the late-stage installation of multiple zinc-binding functionalities via the cleavage of the strained cyclopropane ring in the common pluripoten

Synthesis of chlamydocin by chelate-Claisen rearrangement

Chelate-Claisen rearrangement of a chiral allylic ester allows the synthesis of the unusual epoxyketo amino acid Aoe found in chlamydocin, one representative of a group of peptide-based HDAc inhibitors. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.

Stereospecific synthesis of chlamydocin

A stereospecific synthesis of the cyclic tetrapeptide chlamydocin via free radical homologation from a (S)-2-amino-5-iodopentanoic acid containing cyclic tetrapeptide is described.

Amino Acids and Peptides; 55. Synthesis of Biologically Active Cyclopeptides; 7. Total Synthesis of Chlamydocin

Methods for the synthesis of cyclopeptides containing non-essential amino acids are described.The total synthesis of the highly cancerostatic Chlamydocin is published.

AMINOSAEUREN UND PEPTIDE - XXXXII. SYNTHESE VON CHLAMYDOCIN + EPI-CHLAMYDOCIN

The total synthesis of the cytostatic Chlamydocin together with his diastereomer epi-Chlamydocin is described.

Synthesis of the cytostatic cyclic tetrapeptide, chlamydocin

Chlamydocin has been synthesized by a route utilizing allylic hydroxylation and epoxidation of the DL-2-amino-9-decenoic acid residue to form the 2-amino-8-oxo-9,10-epoxydecanoic acid residue.