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Relevant academic research and scientific papers

Solvatochromism of dye-labeled dendronized polymers of generation numbers 1-4: Comparison to dendrimers

Two series of dendronized polymers (DPs) of generations g = 1-4 with different levels of dendritic substitution (low and high) and a solvatochromic probe at g = 1 level are used to study their swelling behavior in a collection of solvents largely differin

A fluorescently labeled dendronized polymer-enzyme conjugate carrying multiple copies of two different types of active enzymes

A hybrid structure of a synthetic dendronized polymer, two different types of enzymes (superoxide dismutase and horseradish peroxidase), and a fluorescent dye (fluorescein) was synthesized. Thereby, a single polymer chain carried multiple copies of the tw

Tuning polymer thickness: Synthesis and scaling theory of homologous series of dendronized polymers

The thickness of dendronized polymers can be tuned by varying their generation g and the dendron functionality X. Systematic studies of this effect require (i) synthetic ability to produce large samples of high quality polymers with systematic variation o

Directed 1D assembly of a ring-shaped inorganic nanocluster templated by an organic rigid-rod molecule: An inorganic/organic polypseudorotaxane

(Figure Presented) Facing up to matters: Template-assisted cofacial assembly of a ring-shaped polyoxomolybdate cluster (MC) by an oligomeric p-phenylenebutadiynylene rigid rod molecule bearing ammonium ion pendant groups (PBn) allowed for the formation of an inorganic/organic one-dimensional (1D) nanoobject. Studies indicate that the 1D object most likely has a polypseudorotaxane structure (see picture), in which multiple MC rings are threaded by the PBn rod.

Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SKCa)

The synthesis and pharmacological testing of a series of non-peptidic blockers of the SKCa (SK-3) channel is described. Target compounds were designed to mimic the spatial relationships of selected key residues in the energy-minimised structure of the octadecapeptide apamin, which are a highly potent blocker of this channel. Structures consist of a central unit, either a fumaric acid or an aromatic ring, to which are attached two alkylguanidine or two to four alkylaminoquinoline substituents. Potency was tested by the ability to inhibit the SKCa channel-mediated after-hyperpolarization (AHP) in cultured rat sympathetic neurones. It was found that bis-aminoquinoline derivatives are significantly more potent as channel blockers than are the corresponding guanidines. This adds to the earlier evidence that delocalisation of positive charge through the more extensive aminoquinolinium ring system is important for effective channel binding. It was also found that an increase in activity can be gained by the addition of a third aminoquinoline residue to give non-quaternized amines which have submicromolar potencies (IC50 = 0.13-0.36 μM). Extension to four aminoquinoline residues increased the potency to IC50 = 93 nM.

Synthesis of an anionically chargeable, high-molar-mass, second-generation dendronized polymer and the observation of branching by scanning force microscopy

An efficient synthesis of a methacrylate-based, second-generation (G2) dendronized macromonomer and its free radical polymerization to the corresponding high-molar-mass G2 dendronized polymer are described. The molar mass is determined by gel permeation c