886574-91-0

Upstream product

• 446-32-2 4-fluoroanthranilic acid 
• 1175134-33-4 N-methoxy-N-methyl-4-fluoro-2-nitro-benzamide 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 

Downstream Products

• 50817-53-3 (2-amino-4-fluorophenyl)(phenyl)methanone 
• 1175134-51-6 N-methoxy-N-methyl-4-fluoro-2-n-butylamino-benzamide 
• 1175134-49-2 N-methoxy-N-methyl-4-fluoro-2-ethylamino-benzamide 
• 1175134-34-5 N-methoxy-N-methyl-4-fluoro-2-propylamino-benzamide 

Relevant academic research and scientific papers

Catalytic Asymmetric Synthesis of Atropisomeric Quinolines through the Friedl?nder Reaction

A phosphoric acid catalyzed atroposelective Friedl?nder reaction was developed in which acetylacetone and a variety of 2′-substituted 2-Aminobenzophenones were successfully employed to give optically active biaryl quinolines in good yields and with high enantioselectivities.

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present disclosure relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present disclosure also provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

Quinazoline derivatives, process for their preparation, their use as antimitotics and pharmaceutical compositions comprising said derivatives

The invention relates to quinazoline derivatives of formula (I) in which R1, X and A have the meanings as indicated, or to a pharmaceutically acceptable salt thereof, e.g. Such compounds are useful as modulators, in particular inhibitors, of th

Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (Sustiva(TM))

Two series of benzoxazinones differing in the aromatic substitution pattern were prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The 5-fluoro (5a-d) and 6-nitro (5e-h) substituted compounds displayed activity comparable or better than Ef