886576-63-2Relevant academic research and scientific papers
Asymmetric "clip-Cycle" Synthesis of Pyrrolidines and Spiropyrrolidines
Maddocks, Christopher J.,Ermanis, Kristaps,Clarke, Paul A.
supporting information, p. 8116 - 8121 (2020/11/02)
The development of an asymmetric "clip-cycle"synthesis of 2,2- and 3,3-disubstituted pyrrolidines and spiropyrrolidines, which are increasingly important scaffolds in drug discovery programs, is reported. Cbz-protected bis-homoallylic amines were activate
Catalytic cyclization of alkenyl N,O-acetals by Fe(OTf)3
Komeyama, Kimihiro,Igawa, Ryoichi,Morimoto, Takayuki,Takaki, Ken
supporting information; experimental part, p. 724 - 725 (2011/04/21)
Fe(OTf)3, was found to be a good catalyst for the cyclization of alkenyl N,O-acetals to give various nitrogen-containing heterocycles in high yields. Copyright
Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: Enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid
Carlson, Erik C.,Rathbone, Lauren K.,Yang, Hua,Collett, Nathan D.,Carter, Rich G.
, p. 5155 - 5158 (2008/09/21)
(Chemical Equation Presented) An improved protocol for the construction of enantioenriched pyrrolidine, indoline, and piperidine rings using an organocatalyzed, intramolecular heteroatom Michael addition is described. Application to the enantioselective synthesis of homoproline, homopipecolic acid, and pelletierine has been accomplished.
Room temperature palladium-catalyzed intramolecular hydroamination of unactivated alkenes
Michael, Forrest E.,Cochran, Brian M.
, p. 4246 - 4247 (2007/10/03)
A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products is due to the use of a tridentate ligand on Pd which effectively inhibits β-hydride elimination. Copyright
