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Usage

Uses

Used in Pharmaceutical Industry:
Benzyl 2-methylpyrrolidine-1-carboxylate is used as an analgesic and anti-inflammatory agent for the treatment of muscle and joint pain, sore throat, and mouth ulcers. It is effective in reducing pain and inflammation by inhibiting prostaglandin production and decreasing the sensitivity of pain receptors.
Used in Topical Treatments:
Benzyl 2-methylpyrrolidine-1-carboxylate is used as a topical treatment for muscle and joint pain, sore throat, and mouth ulcers. It is available in various pharmaceutical formulations, such as gels, sprays, and lozenges, providing relief from discomfort and inflammation.
Used in Pain Management:
Benzyl 2-methylpyrrolidine-1-carboxylate is used as a pain management agent, providing relief from discomfort and inflammation associated with muscle and joint pain, sore throat, and mouth ulcers. Its local anesthetic properties contribute to its effectiveness in pain relief.

Upstream product

• 61350-66-1 (S)-2-(chloromethyl)-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 86136-88-1 pent-4-enylcarbamic acid benzyl ester 
• 22537-07-1 4-pentenyl-1-amine 
• 501-53-1 benzyl chloroformate 
• 765-38-8 2-methyl-1-pyrrolidine 
• 765-38-8 (S)-2-methylpyrrolidine 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 7736-25-6 2-(pent-4-enyl)-isoindoline-1,3-dione 
• 821-09-0 n-Pent-4-enyl alcohol 

Relevant academic research and scientific papers

Acylative kinetic resolution of racemic methyl-substituted cyclic alkylamines with 2,5-dioxopyrrolidin-1-yl (: R)-2-phenoxypropanoate

The diastereoselective acylation of a number of racemic methyl-substituted cyclic alkylamines with active esters of 2-phenoxypropanoic acid was studied in detail. The ester of (R)-2-phenoxypropanoic acid and N-hydroxysuccinimide was found to be the most selective agent. The highest stereoselectivity was observed in the kinetic resolution of racemic 2-methylpiperidine in toluene at -40 °C (selectivity factor s = 73) with the predominant formation of (R,R)-amide (93.7% de). To explain the observed stereoselectivity, DFT modelling of the transition states in the reactions of the title acylating agent with 2-methylpiperidine and 2-methylpyrrolidine was performed. The calculated values were in good agreement with experimental data. It has been demonstrated that the acylation proceeds via a concerted mechanism, in which the addition of an amine occurs simultaneously with the elimination of the hydroxysuccinimide fragment. The high stereoselectivity of the (R,R)-amide formation is largely ensured by the lower steric hindrances in the transition states as compared to the formation of (R,S)-amide.

Catalytic Reduction of Alkyl and Aryl Bromides Using Propan-2-ol

Milstein's complex, (PNN)RuHCl(CO), catalyzes the efficient reduction of aryl and alkyl halides under relatively mild conditions by using propan-2-ol and a base. Sterically hindered tertiary and neopentyl substrates are reduced efficiently, as well as more functionalized aryl and alkyl bromides. The reduction process is proposed to occur by radical abstraction/hydrodehalogenation steps at ruthenium. Our research represents a safer and more sustainable alternative to typical silane, lithium aluminium hydride, and tin-based conditions for these reductions.

Asymmetric intramolecular hydroamination of alkenes in mild and wet conditions - Structure and reactivity of cationic binuclear gold(I) catalysts

A selected diphosphine binuclear gold(I) chloride complex was combined with a silver salt to catalyze efficiently, for the first time, the asymmetric intramolecular hydroamination of alkenes with high conversions and enantioselectivities, in mild conditions and in presence of water. Both enantiomers of the products could be obtained by controlling the molecular ion-pairs through the solvent polarity. The gold(I) cationic active species was characterized unambiguously at the solid state by X-ray analysis and in solution by DOSY 1H NMR experiments. No contribution of silver chloride was observed on the bonding mode of the catalyst.

Gold(I)-catalyzed intramolecular hydroamination of alkenyl carbamates

(Chemical Equation Presented) Gold for rings: Reaction of alkenyl carbamates such as 1 in the presence of [Au{P(tBu)2(o-biphenyl)}]Cl and AgOTf led to nitrogen heterocycles (e.g. 2). This AuI-catalyzed intramolecular hydroamination t

Room temperature palladium-catalyzed intramolecular hydroamination of unactivated alkenes

A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products is due to the use of a tridentate ligand on Pd which effectively inhibits β-hydride elimination. Copyright

A new class of potent non-imidazole H3 antagonists: 2-Aminoethylbenzofurans

2-Aminoethylbenzofurans constitute a new class of H3 antagonists that are more rotationally constrained than most previously reported H3 antagonists. They retain high potency at human and rat receptors, with efficient CNS penetration observed in 35. The SAR of the basic amine moiety was compared in three different series of analogues. The greatest potency was found in analogues bearing a 2-methylpyrrolidine, a 2,5-dimethylpyrrolidine, or a 2,6-dimethylpiperidine.