886586-69-2Relevant academic research and scientific papers
GUANIDINE DERIVATIVES AS TRPC MODULATORS
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Page/Page column 76, (2014/02/16)
The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists
Poslusney, Michael S.,Sevel, Christian,Utley, Thomas J.,Bridges, Thomas M.,Morrison, Ryan D.,Kett, Nathan R.,Sheffler, Douglas J.,Niswender, Colleen M.,Daniels, J. S.,Conn, P. J.,Lindsley, Craig W.,Wood, Michael R.
, p. 6923 - 6928,6 (2020/09/02)
Utilizing a combination of high-throughput and multi-step synthesis, SAR in a novel series of M1 acetylcholine receptor antagonists was rapidly established. The efforts led to the discovery the highly potent M1 antagonists 6 (VU04312
