886762-99-8

Basic information

• Product Name: [3-(2-BROMO-PHENYL)-PROPYL]-METHYL-AMINE
• Synonyms: [3-(2-BROMO-PHENYL)-PROPYL]-METHYL-AMINE
• CAS NO: 886762-99-8
• Molecular Formula: C₁₀H₁₄BrN
• Molecular Weight: 228.13
• Mol File: 886762-99-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 283.0±23.0 °C(Predicted)
• Appearance: /
• Density: 1.265±0.06 g/cm3(Predicted)
• PKA: 10.48±0.10(Predicted)
• CAS DataBase Reference: [3-(2-BROMO-PHENYL)-PROPYL]-METHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(2-BROMO-PHENYL)-PROPYL]-METHYL-AMINE(886762-99-8)
• EPA Substance Registry System: [3-(2-BROMO-PHENYL)-PROPYL]-METHYL-AMINE(886762-99-8)

Safety Data

• Hazardous Substances Data: 886762-99-8(Hazardous Substances Data)

Usage

General Description

[3-(2-Bromo-phenyl)-propyl]-methyl-amine is a chemical compound with the molecular formula C10H14BrN. It is an amine compound with a methyl group attached to a propyl chain, which in turn is attached to a bromo-phenyl group. [3-(2-BROMO-PHENYL)-PROPYL]-METHYL-AMINE is used in various chemical and pharmaceutical applications, including in the synthesis of organic compounds and as a building block for drug discovery. It can also be used as a reagent in chemical reactions and as a starting material for the production of other complex molecules. The specific properties and uses of this compound will depend on the context and the specific application in which it is being used.

Upstream product

• 15115-58-9 3-(2-bromophenyl)propionic acid 
• 107408-16-2 3-(o-bromophenyl)propanal 
• 74-89-5 methylamine 

Downstream Products

• 917390-00-2 [3-(2-bromo-phenyl)-propyl]-methyl-carbamic acid tert-butyl ester 

Relevant articles and documents

Ni-Catalyzed Carbon-Carbon Bond-Forming Reductive Amination

This report describes a three-component, Ni-catalyzed reductive coupling that enables the convergent synthesis of tertiary benzhydryl amines, which are challenging to access by traditional reductive amination methodologies. The reaction makes use of iminium ions generated in situ from the condensation of secondary N-trimethylsilyl amines with benzaldehydes, and these species undergo reaction with several distinct classes of organic electrophiles. The synthetic value of this process is demonstrated by a single-step synthesis of antimigraine drug flunarizine (Sibelium) and high yielding derivatization of paroxetine (Paxil) and metoprolol (Lopressor). Mechanistic investigations support a sequential oxidative addition mechanism rather than a pathway proceeding via α-amino radical formation. Accordingly, application of catalytic conditions to an intramolecular reductive coupling is demonstrated for the synthesis of endo- and exocyclic benzhydryl amines.

Benzo[b]furane and benzo[b]thiophene derivatives

The present invention relates to benzo[b]furane and benzo[b]thiophene derivatives of the general formula IV as the free base or salts thereof and their use.