88681-04-3

Upstream product

• 21226-30-2 2-chloro-1-(benzenesulfonylamino)benzene 
• 95-51-2 o-chloroaniline 
• 98-09-9 benzenesulfonyl chloride 
• 88680-87-9 benzenesulfonic acid-(4-amino-2-chloro-anilide) 
• 121-87-9 2-Chloro-4-nitroaniline 
• 666996-03-8 N,N-bis-benzenesulfonyl-2-chloro-4-nitro-aniline 

Downstream Products

• 88680-87-9 benzenesulfonic acid-(4-amino-2-chloro-anilide) 
• 6318-10-1 1-benzenesulfonylamino-4-benzoylamino-2-chloro-benzene 

Relevant academic research and scientific papers

Antifungal activities of N-arylbenzenesulfonamides against phytopathogens and control efficacy on wheat leaf rust and cabbage club root diseases.

A set of N-arylbenzenesulfonamides with various substituents at the arylamine and benzenesulfonyl positions were prepared, and their antifungal properties were measured in vitro against such plant pathogenic fungi as Pythium ultimum, Phytophthora capsici, Rhizoctonia solani, and Botrytis cinerea. Compounds 3, 4, 8, 9, 10, 14, 16, 18, 20, 21, 24 and 27 had antifungal activity over a broad spectrum of the phytopathogenic fungi tested, where 50% of inhibition (ED50) was in the range of 3-15 microg/ml. Based on the in vitro activity, six derivatives (3, 4, 10, 18, 21 and 27) were selected and tested further for their fungicidal efficacy in vivo. The fungicidal efficacy of 10, 21 and 27 had a disease control value of over 85% at 50 microg/ml against wheat leaf rust, while that of 4 was selective against cabbage club root disease.

Aniline derivatives

The invention concerns aniline derivatives of formula I STR1 wherein m is 1, 2 or 3, n is 0, 1, 2 or 3, Q is phenyl or naphthyl or a 5- or 6-membered heteroaryl moiety containing 1, 2 or 3 heteroatoms selected from oxygen, nitrogen and sulfur, and X, R1 and R2 are defined in the claims; or pharmaceutical compositions containing them, and the methods of using the compounds as tyrosine kinase inhibitors and for the treatment of proliferative diseases such as cancer.