21226-30-2

Basic information

• Product Name: N-(2-chlorophenyl)benzenesulfonamide
• Synonyms: N-(2-chlorophenyl)benzenesulfonamide
• CAS NO: 21226-30-2
• Molecular Formula: C₁₂H₁₀ClNO₂S
• Molecular Weight: 267.7313
• Mol File: 21226-30-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 402.9°Cat760mmHg
• Flash Point: 197.5°C
• Appearance: /
• Density: 1.405g/cm³
• Vapor Pressure: 1.06E-06mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: N-(2-chlorophenyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chlorophenyl)benzenesulfonamide(21226-30-2)
• EPA Substance Registry System: N-(2-chlorophenyl)benzenesulfonamide(21226-30-2)

Safety Data

• Hazardous Substances Data: 21226-30-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H10ClNO2S/c13-11-8-4-5-9-12(11)14-17(15,16)10-6-2-1-3-7-10/h1-9,14H

Upstream product

• 98-10-2 benzenesulfonamide 
• 15946-36-8 2-chlorobenzenesulfinic acid sodium salt 
• 88-73-3 2-Chloronitrobenzene 
• 98-80-6 phenylboronic acid 
• 603-33-8 triphenylbismuthane 
• 134305-16-1 N-chloro-N-phenylbenzenesulphonamide 
• 60-29-7 diethyl ether 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 7732-18-5 water 
• 124-41-4 sodium methylate 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 110-86-1 pyridine 

Downstream Products

• 1678-25-7 N-phenylbenzenesulfonamide 
• 312-63-0 N-(4-fluorophenyl)benzenesulfonamide 
• 117309-39-4 [Benzenesulfonyl-(2-chloro-phenyl)-amino]-acetic acid 
• 95-51-2 o-chloroaniline 
• 71-43-2 benzene 
• 88681-04-3 N-(2-chloro-4-nitrophenyl)benzenesulfonamide 

Relevant articles and documents

Sequential C-S and S-N Coupling Approach to Sulfonamides

A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite leading to sulfonamides was described. A broad range of sulfonamides bearing different reactive functional groups were obtained in good to excellent yields through sequential C-S and S-N coupling that does not require metal catalysts.

Palladium-catalyzed desulfitative arylation of sulfonamides with sodium arylsulfinates

A Pd(II)-catalyzed desulfitative arylation protocol between sulfonamides and sodium arylsulfinates was herein reported. The direct arylation reaction was successfully achieved by a Pd(II)/Ag(I)-mediated system without participation of any external ligands with a release of SO2. And different N-aryl sulfonamides were obtained readily in up to 86% yields, exhibiting good functional groups tolerance (25 examples).