88704-40-9

Usage

InChI:InChI=1/C11H7BrN2/c12-7-1-2-8-9-3-4-13-6-11(9)14-10(8)5-7/h1-6,14H

Upstream product

• 108061-47-8 7-bromo-1,2,3,4-tetrahydro-β-carboline 
• 96624-18-9 6-bromotryptamine 
• 244-63-3 betacarboline 
• 108061-77-4 6-bromotryptamine hydrochloride 
• 127286-63-9 7-bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid 
• 222173-67-3 3-<(E)-2-nitroethenyl>-6-bromoindole 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 52415-29-9 6-bromo-1H-indole 

Downstream Products

• 222173-69-5 14-<(benzyloxy)methyl>didemnoline A 

Relevant academic research and scientific papers

Substituted beta carbolines

The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, 1which are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of IκB kinase is involved.

Synthesis of didemnolines A-D, N9-substituted β-carboline alkaloids from the marine ascidian Didemnum sp.

Didemnolines A-D (1-4) were synthesized and their structures were confirmed through comparisons of data for the synthetic material with those obtained for natural 1-4. The synthesis of didemnolines A (1) and C (3) involved the coupling of 1-[(benzyloxy)methyl]-4-chloromethyl-5- (thiomethyl)imidazole (6) with 7-bromo-β-carboline (5), while didemnolines B (2) and D (4) were formed through the analogous coupling of 6 with norharmon (7). Intermediate 6 was efficiently prepared from 1-[(benzyloxy)methyl]- 2,4,5-tribromoimidazole using a sequential one-pot halogen-metal exchange reaction and 7-Br-β-carboline was synthesized using a new approach.