88733-50-0Relevant academic research and scientific papers
Convergent synthesis of the quinolone substructure of BILN 2061 via carbonylative sonogashira coupling/cyclization
Haddad, Nizar,Tan, Jonathan,Farina, Vittorio
, p. 5031 - 5034 (2007/10/03)
A convergent synthesis of quinolone 2 (key substructure of the protease inhibitor BILN 2061) was developed via palladium-catalyzed carbonylation of 2-iodo-5-methoxy-aniline (4) with thiazolylacetylene 5.
ORTHO-AMINATION OF LITHIATED TERTIARY BENZAMIDES. SHORT ROUTE TO POLYSUBSTITUTED ANTHRANILAMIDES
Reed, J. N.,Snieckus, V.
, p. 3795 - 3798 (2007/10/02)
Directed lithiation of benzamides (1), phenyloxazoline (4a), methoxymethoxybenzene (4b), and O-phenyl carbamate (4c) followed by sequential treatment with TsN3 and NaBH4 constitutes a general route to synthetically useful amino aromatics 3 and 5.
