887474-76-2Relevant academic research and scientific papers
Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors
Belanger, David B.,Curran, Patrick J.,Hruza, Alan,Voigt, Johannes,Meng, Zhaoyang,Mandal, Amit K.,Siddiqui, M. Arshad,Basso, Andrea D.,Gray, Kimberly
scheme or table, p. 5170 - 5174 (2010/10/02)
The synthesis and structure-activity relationships (SAR) of novel, potent imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors are described. The X-ray crystal structure of imidazo[1,2-a]pyrazine Aurora inhibitor 1j is disclosed. Compound 10i was identified as lead compound with a promising overall profile.
Methods for inhibiting protein kinases
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Page/Page column 161, (2010/11/27)
The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
Imidazopyrazines as protein kinase inhibitors
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Page/Page column 88, (2010/11/27)
In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.
