887495-80-9Relevant academic research and scientific papers
Discovery of novel biaryl heterocyclic EP1 receptor antagonists
Hall, Adrian,Bit, Rino A.,Brown, Susan H.,Chaignot, Helene M.,Chessell, Iain P.,Coleman, Tanya,Giblin, Gerard M.P.,Hurst, David N.,Kilford, Ian R.,Lewell, Xiao Q.,Michel, Anton D.,Mohamed, Shiyam,Naylor, Alan,Novelli, Riccardo,Skinner, Lee,Spalding, David J.,Tang, Sac P.,Wilson, Richard J.
, p. 2666 - 2671 (2007/10/03)
We describe the generation of novel EP1 receptor antagonists by investigation of thiophene isosteres. In addition, we disclose preliminary in vitro and in vivo DMPK for selected compounds.
