887591-34-6

Basic information

• Product Name: 2-CYANO-1-(5-FLUORO-2-METHOXY-PHENYL)-ETHANONE
• Synonyms: 3-(5-FLUORO-2-METHOXY-PHENYL)-3-OXO-PROPIONITRILE;2-CYANO-1-(5-FLUORO-2-METHOXY-PHENYL)-ETHANONE;3-(5-fluoro-2-methoxyphenyl)-3-oxopropanenitrile
• CAS NO: 887591-34-6
• Molecular Formula: C₁₀H₈FNO₂
• Molecular Weight: 193.17
• Mol File: 887591-34-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CYANO-1-(5-FLUORO-2-METHOXY-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-1-(5-FLUORO-2-METHOXY-PHENYL)-ETHANONE(887591-34-6)
• EPA Substance Registry System: 2-CYANO-1-(5-FLUORO-2-METHOXY-PHENYL)-ETHANONE(887591-34-6)

Safety Data

• Hazardous Substances Data: 887591-34-6(Hazardous Substances Data)

Upstream product

• 445-82-9 1-(5-fluoro-2-methoxyphenyl)ethanone 
• 343-04-4 2-bromo-1-(5-fluoro-2-methoxyphenyl)ethan-1-one 
• 143-33-9 sodium cyanide 

Downstream Products

• 934340-27-9 C₁₃H₁₂FNO₄ 

Relevant articles and documents

3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors

The C-3 substituents effect on NHE-1 inhibitory activity of (5-arylfuran-2-ylcarbonyl)guanidines, previously identified as potent NHE-1 inhibitors, was investigated. The introduction of amine or alkyl groups at the 3-position of the furan ring, next to the acylguanidine moiety, remarkably improves NHE-1 inhibitory potency. Especially the important finding is that 5-(2,5-dichloro)phenyl and 5-(2-methoxy-5-chloro)phenyl derivatives exhibit high NHE-1 inhibitory activities (IC50 0.02 μM) that match those of 3-unsubstituted derivatives.