445-82-9

Usage

Uses

Used in Pharmaceutical Research and Development:
5-FLUORO-2-METHOXYACETOPHENONE is used as an intermediate in the production of various drugs and other organic compounds. Its unique structure allows for the development of new drugs with therapeutic properties, contributing to the advancement of pharmaceutical research.
Used in Organic Synthesis:
In the field of organic synthesis, 5-FLUORO-2-METHOXYACETOPHENONE serves as a valuable building block for the synthesis of complex organic molecules. Its presence of a fluorine atom and a methoxy group at specific positions on the acetophenone molecule enables the creation of diverse chemical structures with potential applications in various industries.
Used in Medicinal Chemistry:
5-FLUORO-2-METHOXYACETOPHENONE is utilized in medicinal chemistry for the design and synthesis of novel compounds with potential therapeutic effects. Its unique structural features make it a promising candidate for the development of new drugs and the improvement of existing ones.
Used in Drug Discovery:
In the process of drug discovery, 5-FLUORO-2-METHOXYACETOPHENONE plays a crucial role as a starting material for the synthesis of potential drug candidates. Its versatility in chemical reactions allows researchers to explore various chemical modifications, leading to the identification of new compounds with improved pharmacological properties.
Used in Chemical Research:
5-FLUORO-2-METHOXYACETOPHENONE is also employed in chemical research to study the effects of fluorination and methoxylation on the reactivity and properties of acetophenone derivatives. This knowledge can be applied to the development of new synthetic methods and the understanding of structure-activity relationships in various chemical systems.

Upstream product

• 579-74-8 2-Methoxyacetophenone 
• 75-16-1 methylmagnesium bromide 
• 189628-38-4 5-fluoro-2-methoxybenzonitrile 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 75-36-5 acetyl chloride 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 394-04-7 5-fluoro-2-methoxybenzoic acid 
• 446-77-5 2-(5-fluoro-2-methoxy-phenyl)-quinoline-4-carboxylic acid 
• 71313-97-8 2-(5-fluoro-2-methoxyphenyl)propan-2-ol 
• 62433-40-3 [4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-p-tolyl-amine 
• 62433-44-7 [4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-o-tolyl-amine 
• 62433-46-9 [4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-(4-methoxy-phenyl)-amine 
• 62433-45-8 [4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-(2-methoxy-phenyl)-amine 
• 62433-43-6 (4-chloro-phenyl)-[4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-amine 
• 887591-34-6 C₁₀H₈FNO₂ 
• 934340-27-9 C₁₃H₁₂FNO₄ 
• 104029-18-7 Ethyl 2-methoxy-5-fluorobenzoylacetate 
• 71313-98-9 2-(5-fluoro-2-hydroxyphenyl)-2-(5-fluoro-2-methoxyphenyl)-propane 
• 179111-05-8 3-bromo-6-fluoro-4H-chromen-4-one 

Relevant academic research and scientific papers

PROCESSES FOR THE PREPARATION OF FUNGICIDAL COMPOUNDS

Provided herein are processes for the preparation of stereomerically enriched compounds of Formulas I-014, I-020, I-064, I-074, I-082, I-089, I-090, I-095, I-171, I-181, I-184, I-186, I-189, I-191, I-192, I-193, I-205, I-206, I-208, I-211, I-212, I-213, I-220, I-229, I-231, I-233, I-234, I-246, I-251, I-258, I-259, I-262, I-263, I-285, I-323 and I-400. The compounds described herein exhibit activity as pesticides and are useful, for example, in methods for the control of fungal pathogens and diseases caused by fungal pathogens in plants. A preferred process is directed to preparing a stereomerically enriched compound of Formula V-1 or V-2-F by assymetrical reduction in the presence of a chiral organometallic catalyst.

Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis

Two new series of ring-opened analogues of cromakalim bearing sulfonylurea moieties (series A: with N-unmethylated sulfonylureas, series B: with N-methylated sulfonylureas) were synthesized and tested as relaxants of vascular and respiratory smooth muscle

Chromenones as potent bradykinin B1 antagonists

A series of fused 6,6-bicyclic chromenones was investigated for activity against the bradykinin B1 receptor. SAR studies based on a pharmacophore model revealed compounds with high affinity for both human and rabbit B1. These compounds demonstrated favorable pharmacokinetic properties and 5-chlorochromenone 15 was efficacious in a carrageenan-induced mechanical hyperalgesia model for chronic pain.

Rate of Enolate Formation Is Not Very Sensitive to the Hydrogen Bonding Ability of Donors to Carboxyl Oxygen Lone Pair Acceptors; A Ramification of the Principle of Non-Perfect Synchronization for General-Base-Catalyzed Enolate Formation

Two series of structures (1 and 2) possessing intramolecular hydrogen bonds to the lone-pair electrons of carbonyl oxygens have been examined to reveal the influence of the pKa of the hydrogen-bond donor on the rate of general-base-catalyzed enolate formation. The geometry of the hydrogen bonds is well accepted to be appropriate for intramolecular hydrogen-bond formation. Yet, as revealed by Bronsted plots, both series show very little dependence of the rate of enolate formation on the hydrogen-bond donor ability. The intramolecular hydrogen bonds give rate enhancements only on the order of 10-100-fold, and corrected Bronsted α-values are slightly below 0.1. The results can be understood by interpreting them in light of the Principle of Non-Perfect Synchronization. The results are consistent with the proton transfer occurring through an asynchronous transition state with the developing negative charge localized on carbon. We postulate that catalysts of enolate formation will be most effective if the binding groups are focused on stabilizing negative charge that is forming on the enolate carbon rather than on the enolate oxygen.

Solvent directing immediate fluorination of aromatic ketones using 1- fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)

Reactions of aryl alkyl ketones with 1-fluoro-4-hydroxy1,4- diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Accufluor(TM) NFTh) in methanol result in selective and almost quantitative formation of the corresponding α-fluoroketones, while in acetonitrile exclusive fluorofunctionalisation of the activated aromatic ring take place.

Process for killing internal helminths using certain 1,1-bis-(2-substituted-3-nitrophenyl)alkane or alkylene derivatives

A method for killing internal parasites of warm blooded animals by treating the animals with an effective amount of a composition comprising a bis-(2-hydroxy-3-nitrophenyl)methane derivative; and novel bis(2-hydroxy-3-nitrophenyl)methane derivatives.