445-82-9

Basic information

• Product Name: 5-FLUORO-2-METHOXYACETOPHENONE
• Synonyms: 1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE;5'-FLUORO-2'-METHOXYACETOPHENONE;5-FLUORO-2-METHOXYACETOPHENONE;Albb-004400;1-(5-Fluoro-2-methoxyphenyl)ethanon
• CAS NO: 445-82-9
• Molecular Formula: C₉H₉FO₂
• Molecular Weight: 168.16
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Fluorine series
• Mol File: 445-82-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 23 °C
• Boiling Point: 246.8 °C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 1.1880
• Refractive Index: 1.5180
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-FLUORO-2-METHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2-METHOXYACETOPHENONE(445-82-9)
• EPA Substance Registry System: 5-FLUORO-2-METHOXYACETOPHENONE(445-82-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 445-82-9(Hazardous Substances Data)

Usage

General Description

5-FLUORO-2-METHOXYACETOPHENONE is a synthetic chemical compound that belongs to the class of acetophenone derivatives. It is characterized by the presence of a fluorine atom at the fifth position and a methoxy group at the second position of the acetophenone molecule. 5-FLUORO-2-METHOXYACETOPHENONE is used in organic synthesis and pharmaceutical research as an intermediate in the production of various drugs and other organic compounds. It has potential applications in the development of new drugs with therapeutic properties. Additionally, 5-FLUORO-2-METHOXYACETOPHENONE can also be used as a building block for the synthesis of complex organic molecules in the field of medicinal chemistry and drug discovery.

Upstream product

• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 74-88-4 methyl iodide 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 75-36-5 acetyl chloride 
• 75-16-1 methylmagnesium bromide 
• 189628-38-4 5-fluoro-2-methoxybenzonitrile 
• 579-74-8 2-Methoxyacetophenone 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 343-04-4 2-bromo-1-(5-fluoro-2-methoxyphenyl)ethan-1-one 
• 887591-34-6 C₁₀H₈FNO₂ 
• 934340-27-9 C₁₃H₁₂FNO₄ 
• 179111-05-8 3-bromo-6-fluoro-4H-chromen-4-one 
• 1354928-53-2 C₁₇H₁₁FO₄ 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF FUNGICIDAL COMPOUNDS

Provided herein are processes for the preparation of stereomerically enriched compounds of Formulas I-014, I-020, I-064, I-074, I-082, I-089, I-090, I-095, I-171, I-181, I-184, I-186, I-189, I-191, I-192, I-193, I-205, I-206, I-208, I-211, I-212, I-213, I-220, I-229, I-231, I-233, I-234, I-246, I-251, I-258, I-259, I-262, I-263, I-285, I-323 and I-400. The compounds described herein exhibit activity as pesticides and are useful, for example, in methods for the control of fungal pathogens and diseases caused by fungal pathogens in plants. A preferred process is directed to preparing a stereomerically enriched compound of Formula V-1 or V-2-F by assymetrical reduction in the presence of a chiral organometallic catalyst.

Chromenones as potent bradykinin B1 antagonists

A series of fused 6,6-bicyclic chromenones was investigated for activity against the bradykinin B1 receptor. SAR studies based on a pharmacophore model revealed compounds with high affinity for both human and rabbit B1. These compounds demonstrated favorable pharmacokinetic properties and 5-chlorochromenone 15 was efficacious in a carrageenan-induced mechanical hyperalgesia model for chronic pain.

Solvent directing immediate fluorination of aromatic ketones using 1- fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)

Reactions of aryl alkyl ketones with 1-fluoro-4-hydroxy1,4- diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Accufluor(TM) NFTh) in methanol result in selective and almost quantitative formation of the corresponding α-fluoroketones, while in acetonitrile exclusive fluorofunctionalisation of the activated aromatic ring take place.