887641-65-8Relevant academic research and scientific papers
Highly adequate oxidative esterification of α-carbonyl aldehydes with alkyl halides in TBAI/TBHP mediated system
Bhargude, Pooja L.,Lade, Jatin J.,Patil, Bhausaheb N.,Vadagaonkar, Kamlesh S.,Chaskar, Atul C.
, p. 1325 - 1333 (2019)
An efficient and viable synthesis of α-ketoesters from alkyl halides and α-carbonyl aldehydes has been reported under metal-free conditions. The present method involves oxidative esterification of α-carbonyl aldehydes with alkyl halide using TBAI as a promoter and TBHP as an oxidant to form α-ketoesters in good to excellent yields with versatile structural diversity. Use of commercially accessible and inexpensive substrates, broad substrate scope and good functional group tolerance are the key features of this protocol.
I2-promoted cross-dehydrogenative coupling of α-carbonyl aldehydes with alcohols for the synthesis of α-ketoesters
Sagar,Vidyacharan, Shinde,Sharada, Duddu S.
, p. 37047 - 37050 (2014/11/08)
A facile and efficient method for the synthesis of α-ketoesters from alcohols and α-carbonyl aldehydes has been developed at room temperature under metal-free conditions for the first time. Various alcohols and α-carbonyl aldehydes could participate in this reaction to afford the desired products in excellent yields. the Partner Organisations 2014.
Rhodium-catalyzed intermolecular reaction of alkyl azides with diazo(aryl)acetates
Gu, Peiming,Wu, Xiu-Ping,Su, Yan,Li, Xue-Qiang,Xue, Ping,Li, Rui
, p. 535 - 538 (2014/03/21)
An efficient intermolecular interception of alkyl azides by diazo(aryl)acetates was achieved in the presence of dirhodium tetraoctanoate. The initial products were unstable α-imino esters, and overaddition of carbenoids to the C-N double bonds was avoided. After acidic workup, the corresponding α-keto esters were obtained in good to excellent yields. Georg Thieme Verlag Stuttgart New York.
