887641-75-0Relevant academic research and scientific papers
Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of α-Iminoesters
Chen, Jianzhong,Li, Feilong,Wang, Fang,Hu, Yawen,Zhang, Zhenfeng,Zhao, Min,Zhang, Wanbin
, p. 9060 - 9065 (2019/11/19)
An efficient Pd(OAc)2-catalyzed asymmetric hydrogenation of α-iminoesters was realized for the first time at 1 atm hydrogen pressure and room temperature. Pd(OAc)2, a less expensive Pd salt with low toxicity, was found to be the most suitable catalyst precursor rather than Pd(TFA)2 which is usually the catalyst of choice for homogeneous asymmetric hydrogenation. The chiral α-arylglycine fragments are widely found in many chiral products and bioactive molecules.
Highly adequate oxidative esterification of α-carbonyl aldehydes with alkyl halides in TBAI/TBHP mediated system
Bhargude, Pooja L.,Lade, Jatin J.,Patil, Bhausaheb N.,Vadagaonkar, Kamlesh S.,Chaskar, Atul C.
supporting information, p. 1325 - 1333 (2019/04/30)
An efficient and viable synthesis of α-ketoesters from alkyl halides and α-carbonyl aldehydes has been reported under metal-free conditions. The present method involves oxidative esterification of α-carbonyl aldehydes with alkyl halide using TBAI as a promoter and TBHP as an oxidant to form α-ketoesters in good to excellent yields with versatile structural diversity. Use of commercially accessible and inexpensive substrates, broad substrate scope and good functional group tolerance are the key features of this protocol.
Rhodium-catalyzed intermolecular reaction of alkyl azides with diazo(aryl)acetates
Gu, Peiming,Wu, Xiu-Ping,Su, Yan,Li, Xue-Qiang,Xue, Ping,Li, Rui
supporting information, p. 535 - 538 (2014/03/21)
An efficient intermolecular interception of alkyl azides by diazo(aryl)acetates was achieved in the presence of dirhodium tetraoctanoate. The initial products were unstable α-imino esters, and overaddition of carbenoids to the C-N double bonds was avoided. After acidic workup, the corresponding α-keto esters were obtained in good to excellent yields. Georg Thieme Verlag Stuttgart New York.
Enantioselective rhodium-catalyzed addition of arylboronic acids to α-ketoesters
Duan, Hai-Feng,Xie, Jian-Hua,Qiao, Xiang-Chen,Wang, Li-Xin,Zhou, Qi-Lin
supporting information; experimental part, p. 4351 - 4353 (2009/02/08)
(Chemical Figure Presented) Rhodium catalysis: The first example of a catalytic asymmetric addition of arylboronic acids to α-ketoesters was realized by using a chiral RhI-spirophosphite ligand complex in aqueous solvent to provide tertiary α-hydroxyesters in good yields with high enantioselectivities (see scheme; DCE = 1,2-dichloroethane).
