887669-43-4

Upstream product

• 1350840-01-5 N-benzyloxy-2-(2-bromophenyl)acetamide 
• 18698-97-0 ortho-bromophenylacetic acid 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 78158-32-4 N-(benzyloxy)-2-bromoacetamide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 18108-55-9 1,3-dihydro-1-hydroxyindole-2-one 
• 1072810-13-9 1-(benzyloxy)-3,3-dimethylindolin-2-one 

Relevant academic research and scientific papers

Metal- and Oxidant-Free Modular Approach to Access N-Alkoxy Oxindoles via Aryne Annulation

An unprecedented metal- and oxidant-free (intermolecular) approach to access N-alkoxy oxindoles via [3 + 2] cycloadition of in situ generated electrophilic species viz. aryne and (putative) aza-oxyallyl cation is reported. This approach is amenable to both C3-unsubstituted as well as C3-substituted oxindoles. A one-pot manipulation further makes this reaction highly practical. The versatility of this approach was demonstrated through valuable synthetic transformations.

Synthesis of N-alkoxyindol-2-ones by copper-catalyzed intramolecular N-arylation of hydroxamates

The first example of copper-catalyzed intramolecular N-arylation of hydroxamic acid derivatives is presented. Based on this transformation a new method for the synthesis of N-alkoxyindol-2-ones from 2-(2-bromoaryl) acetylhydroxamates has been developed. T