88767-13-9 Usage
Classification
Cyclitol nucleoside
Structure
Consists of a pyrrolopyrimidine ring connected to a cyclopentanediol moiety
Pharmaceutical applications
Antitumor agent, anti-viral agent
Antiviral activity
Studied against HIV-1 and herpes simplex virus
Potential drug development
Investigated as a nucleoside mimic and analog for use in drug development
Check Digit Verification of cas no
The CAS Registry Mumber 88767-13-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,7,6 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 88767-13:
(7*8)+(6*8)+(5*7)+(4*6)+(3*7)+(2*1)+(1*3)=189
189 % 10 = 9
So 88767-13-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N4O3/c13-11-7-1-2-16(12(7)15-5-14-11)8-3-6(4-17)9(18)10(8)19/h1-2,5-6,8-10,17-19H,3-4H2,(H2,13,14,15)/t6-,8-,9-,10+/m0/s1
88767-13-9Relevant articles and documents
(+/-)-3-(4-Amino-1H-pyrrolopyrimidin-1-yl)-5-(hydroxymethyl)-(1α,2α,3β,5β)-1,2-cyclopentanediol, the Carbocyclic Analogue of Tubercidin
Secrist, John A.,Clayton, Sarah Jo,Montgomery, John A.
, p. 534 - 536 (1984)
(+/-)-3-(4-Amino-1H-pyrrolopyrimidin-1-yl)-5-(hydroxymethyl)-(1α,2α,3β,5β)-1,2-cyclopentanediol (9), the carbocyclic analogue of tubercidin, prepared from (+/-)-3-amino-5-(hydroxymethyl)-(1α,2α,3β,5β)-1,2-cyclopentanediol (6), is cytotoxic to cells containing adenosine kinase but not to cells that do not, indicating that its activity depends on phosphorylation.Although inactive against P388 leukemia in mice and against herpes and influenza viruses in vitro, it showed marginal activity against respiratory syncytial, vesicular stomatitis, and rhino viruses in vitro.
