88767-98-0Relevant articles and documents
LIPOPHILIC MACROCYCLIC LIGANDS, COMPLEXES THEREOF, AND USES OF SAME
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Paragraph 0168-0171, (2020/08/05)
The present invention relates to novel lipophilic macrocyclic ligands, the complexes thereof, in particular radioactive complexes, and the uses of same in medical imaging and/or in therapy, in particular in interventional radiology.
SYNTHESIS OF N-ALKYL-1,2,4-OXADIAZINONES AS ANGIOTENSIN-II (AT1) RECEPTOR ANTAGONISTS
Weller, Harold N.,Miller, Arthur V.,Dickinson, Kenneth E.,Hedberg, S. Anders,Delaney, Carol L.,et al.
, p. 1027 - 1038 (2007/10/02)
4-Alkyl-1,2,4-oxadiazinones were prepared by regiospecific alkylation of the corresponding 4H-oxadiazinones, which were synthesized by a trimethylaluminium mediated cyclization reaction.Alkylation was regiospecyfic and generally facile; in one example, however, an unusual fragmentation reaction occurred.A homochiral oxadiazineone was also prepared and alkylated under the described conditions. 4-Biphenylmethyl-1,2,4-oxadi-azinones were potent angiotensin-II receptor antagonists.
The Design and Synthesis of the Angiotensin Converting Enzyme Inhibitor Cilazapril and Related Bicyclic Compounds
Attwood, Michael R.,Hassall, Cedric H.,Kroehn, Antonin,Lawton, Geoffrey,Redshaw, Sally
, p. 1011 - 1020 (2007/10/02)
The postulated binding functions for the active site of Angiotensin Converting Enzyme (A.C.E.), derived in an earlier study, have made possible the design of improved inhibitors.Consequently, (1S,9S)-9-octahydro-10-oxo-6H-pyridazodiazepine-1-carboxylic acid (Cilazapril), and related compounds, have been synthesized.They are very active inhibitors of A.C.E. and are highly potent antihypertensives in vivo.