88768-40-5 Usage
Description
Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat. In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension.
Chemical Properties
Off-White Solid
Uses
Different sources of media describe the Uses of 88768-40-5 differently. You can refer to the following data:
1. An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive
2. An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.
Brand name
Inhibace (Hoffmann-LaRoche).
Check Digit Verification of cas no
The CAS Registry Mumber 88768-40-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,7,6 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 88768-40:
(7*8)+(6*8)+(5*7)+(4*6)+(3*8)+(2*4)+(1*0)=195
195 % 10 = 5
So 88768-40-5 is a valid CAS Registry Number.
InChI:InChI=1/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1
88768-40-5Relevant articles and documents
PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF CILAZAPRIL
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Page/Page column 10, (2012/05/04)
The present invention relates to a process for the preparation of optically pure (S,S)-6-t-butoxycarbonyl-hexahydro-1-pyridazinylcarbonyl-1,3-dioxo-2-isoindolebutyric acid, an intermediate for the preparation of cilazapril.
ENANTIOMERICALLY PURE CILAZAPRIL,PROCESS FOR PREPARATION
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Page 5-6, (2008/06/13)
The invention relates to enantiomerically pure cilazapril and a process for preparing enantiomerically pure cilazapril. The invention also relates to pharmaceutical compositions that include the enantiomerically pure cilazapril and use of said composition