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Upstream product

• 32781-14-9 (Z)-6-chloro-3-(2-oxo-2-phenylethylidene)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-one 
• 79-37-8 oxalyl dichloride 
• 39847-99-9 (Z)-methyl 2-hydroxy-4-oxo-4-phenylbut-2-enoate 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 5817-92-5 2,4-dioxo-4-phenylbutanoic acid 

Relevant academic research and scientific papers

Facile approach to alkaloid-like 6/6/5/5-tetracyclic spiroheterocycles via 1,3-dipolar cycloaddition reaction of fused 1H-pyrrole-2,3-diones with nitrones

A facile synthetic approach towards 6/6/5/5-tetracyclic spiroheterocycles has been developed from the highly diastereoselective 1,3-dipolar cycloaddition reaction of [e]-fused 1H-pyrrole-2,3-diones with nitrones. The described novel heterocyclic systems are heteroanalogs of cytotoxic alkaloids, kibalaurifoline and gitingensine. The developed reaction represents the first example of involvement of 1H-pyrrole-2,3-diones fused at [e]-side in a 1,3-dipolar cycloaddition reaction.

Five-membered 2,3-dioxo heterocycles: XCVIII.* [4 + 2]-cycloaddition of alkyl vinyl ethers to 3-aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4- triones. A new synthetic approach to heteroanalogs of 13(14→8)-abeo steroids

3-Aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones reacted with alkyl vinyl ethers according to the [4 + 2]-cycloaddition pattern with formation of substituted (1S*,16R*)- and (1R*,16R*)-16-alkoxy-14- aryl-3,15-dioxa-10-azatetracyclo[8.7.0.01,13.04,9

Five-membered 2,3-dioxo heterocycles: LXXVII. [4 + 2]-cycloaddition of alkyl vinyl ethers to 3-aroylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4(4H)-triones

[4 + 2]-Cycloaddition of 3-aroylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4(4H)- triones to alkyl vinyl ethers gave substituted stereoisomeric (1R,16R)- and (1S,16R*)-16-alkoxy-14-aryl-3,15-dioxa-10-azatetracyclo[ 8.7.0.0 1,13.04,9]heptadec

Chemistry of acyl(imidoyl)ketenes: IX. Synthesis and thermolysis of 3-aroyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones

Reactions of 3-Z-aroylmethylene-6-chloro-3,4-dihydro-2H-1,4-benzoxazine-2- ones with oxalyl chloride afford 3-aroyl-8-chloro-1,2-dihydro-4H-pyrrolo[2,1-c] [1,4]benzoxazine-1,2,4-triones and Z-3-(2-aryl-2-chlorovinyl)-6-chloro-2H-1,4- benzoxazine-2-ones. A