88783-75-9

Upstream product

• 1222-98-6 4-nitrochalcone 
• 109-77-3 malononitrile 
• 2960-55-6 (E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 
• 98-86-2 acetophenone 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 89451-24-1 4-(4-Chloro-phenyl)-6-hydroxy-6-phenyl-2-thioxo-piperidine-3-carbonitrile; compound with piperidine 
• 89451-37-6 (3S,4S)-4-(4-Chloro-phenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile 
• 89451-37-6 (3R,4S)-4-(4-Chloro-phenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile 
• 89451-38-7 4-(4-Chloro-phenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile; compound with piperidine 
• 78564-16-6 4-(4-Chlor-phenyl)-6-phenyl-2-thioxo-1,2-dihydro-pyridin-3-carbonitril 

Relevant academic research and scientific papers

Design, synthesis and structure-activity relationship of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure as multi-target inhibitors against receptor tyrosine kinase

Inspired by that the multi-target inhibitors against receptor tyrosine kinases (RTKs) have significantly improved the effect of clinical treatment for cancer, and based on the chemical structure of Linifanib (ABT-869, Abbott), two series of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure were designed and synthesized as multi-target inhibitors against RTKs. The preliminary biological evaluation showed that several compounds exhibited comparable potency with Linifanib. Compound S21 was identified as the most potent inhibitor against Fms-like tyrosine kinase 3 (FLT-3), kinase insert domain containing receptor (KDR) and platelet-derived growth factor receptor β (PDGFR-β) with its IC50 values were 4 nM, 3 nM and 8 nM respectively, it also showed potent inhibitory activities against several cancer cells.

Conjugate addition of malononitrile on chalcone: Biocatalytic [Formula presented] bond formation

An efficient, cost effective and environmentally friendly protocol has been developed for the Michael addition of malononitrile on 1,3-diaryl-2-propen-1-ones (Chalcones) using very cheaper, easily available natural catalyst, baker's yeast. The whole cells of yeast excellently worked in nonaqueous medium, ethanol without decrease in catalytic activity.

A mild and convenient one-pot synthesis of 4,6-diaryl- 3-aminoisoxazolo[3, 4-b]pyridines

We have developed a convenient method for the synthesis of a series of new 4,6-diaryl-3-aminoisoxazolo[3,4-b]pyridines through one-pot reaction starting from the easily available chalcones, malononitrile, and hydroxylamine. This class of compounds might h

An active and selective heterogeneous catalytic system for Michael addition

Potassium fluoride doped natural zeolite was found to be an efficient and selective solid base catalyst for 1,4-Michael addition. The catalyst is easily prepared and the workup procedure simplified by simple filtration. All products were obtained in high