78564-16-6

Basic information

• Product Name: 4-(4-chlorophenyl)-6-phenyl-2-sulfanylidene-1H-pyridine-3-carbonitrile
• Synonyms: 4-(4-chlorophenyl)-6-phenyl-2-sulfanylidene-1H-pyridine-3-carbonitrile;4-(4-chlorophenyl)-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile
• CAS NO: 78564-16-6
• Molecular Formula: C₁₈H₁₁ClN₂S
• Molecular Weight: 322.81134
• Mol File: 78564-16-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 470.6°Cat760mmHg
• Flash Point: 238.4°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 4.99E-09mmHg at 25°C
• Refractive Index: 1.716
• CAS DataBase Reference: 4-(4-chlorophenyl)-6-phenyl-2-sulfanylidene-1H-pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenyl)-6-phenyl-2-sulfanylidene-1H-pyridine-3-carbonitrile(78564-16-6)
• EPA Substance Registry System: 4-(4-chlorophenyl)-6-phenyl-2-sulfanylidene-1H-pyridine-3-carbonitrile(78564-16-6)

Safety Data

• Hazardous Substances Data: 78564-16-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H11ClN2S/c19-14-8-6-12(7-9-14)15-10-17(13-4-2-1-3-5-13)21-18(22)16(15)11-20/h1-10H,(H,21,22)

Upstream product

• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 88783-75-9 2-(1-(4-nitrophenyl)-3-oxo-3-phenylpropyl)malononitrile 
• 24721-26-4 4-chlorochalcone 
• 68029-53-8 (E)-3-(4-chlorophenyl)-2-cyanoprop-2-enethioamide 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 109-77-3 malononitrile 
• 89451-24-1 4-(4-Chloro-phenyl)-6-hydroxy-6-phenyl-2-thioxo-piperidine-3-carbonitrile; compound with piperidine 
• 89451-38-7 4-(4-Chloro-phenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile; compound with piperidine 
• 77609-09-7 3-(4-chlorophenyl)-2-cyano-5-phenyl-5-oxo-pentano-nitrile 
• 7357-70-2 Cyanothioacetamide 

Downstream Products

• 143882-81-9 [4-(4-Chloro-phenyl)-3-cyano-6-phenyl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester 
• 152068-93-4 Ni((ClC₆H₄)(C₆H₅)C₅HNS(CN))2 
• 143882-86-4 3-Amino-4-(4-chloro-phenyl)-6-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 94639-62-0 9-(4-Chlorphenyl)-2-methyl-4-oxo-4H-7-phenylpyrido<3',2':4,5>thieno<3,2-d>-1,3-oxazin 
• 94639-83-5 3-Amino-4-(4-chlorphenyl)-6-phenylthieno<2,3-b>pyridin-2-carbonsaeure 
• 94639-92-6 4-(4-Chloro-phenyl)-6-phenyl-thieno[2,3-b]pyridin-3-ylamine 
• 128917-97-5 3-Amino-4-(4-chloro-phenyl)-6-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid amide 
• 148206-00-2 3-Amino-4-(4-chlorphenyl)-6-phenylthieno<2,3-b>pyridin-2-carbonsaeuremethylester 
• 151058-49-0 3-Amino-4-(4-chloro-phenyl)-6-phenyl-thieno[2,3-b]pyridine-2-carbonitrile 
• 78564-25-7 C₃₆H₂₀Cl₂N₄S₂ 
• 94640-07-0 [4-(4-Chloro-phenyl)-3-cyano-6-phenyl-pyridin-2-ylsulfanyl]-acetic acid 

Relevant articles and documents

Unexpected formation of 4-aryl-3-cyano-6-phenylpyridine-2(1H)-thiones from the reaction of arylmethylenecyanothioacetamides with benzoyl-1,1,1- trifluoroacetone

4-Aryl-3-cyano-6-phenylpyridine-2(1H)-thiones, used in the synthesis of substituted 2-alkylthiopyridines, thieno[2,3-b]pyridines, and 1,4-di(pyridin-2-ylthio)butane, have been synthesized by the condensation of arylmethylenecyanothioacetamides with benzoyl-1,1,1-trifluoroacetone. The reaction path includes the formation of the Michael adduct which undergoes loss of the acyl group. The structure of 3-cyano-2-methylthio-4-(1-naphthyl)-6- phenylpyridine has been studied by X-ray crystallography. 2005 Springer Science+Business Media, Inc.

Synthesis of N-(2-carboxy-thieno[2,3-b]pyridin-3-yl)amidines by the reaction of 4-oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]1,3-oxazines with secondary cycloaliphatic amines

4-Oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]1,3-oxazines react with secondary cycloaliphatic amines to give besides the expected bisamides the amine salts of N-(2-carboxy-thieno[2,3-b]pyridine-3-yl)amidines. These compounds showed inhibitory activity against different lipoxygenases, but a small chemical stability.

CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES

2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.