888482-29-9Relevant articles and documents
Aromatic spiroketal bisphosphine ligands: Palladium-catalyzed asymmetric allylic amination of racemic Morita-Baylis-Hillman adducts
Wang, Xiaoming,Meng, Fanye,Wang, Yan,Han, Zhaobin,Chen, Yong-Jun,Liu, Li,Wang, Zheng,Ding, Kuiling
, p. 9276 - 9282 (2012/10/29)
Showing a backbone: The spiroketal backbone of the bis(phosphine) ligand 1 led to good regio- and enantioselectivity in the palladium-catalyzed asymmetric allylic amination of racemic Morita-Baylis-Hillman adducts with aromatic amines. The methodology provides a facile and efficient synthesis of precursors for optically active β-lactam derivatives, including the cholesterol drug Ezetimibe.
Asymmetric Synthesis of trans and cis β-Lactams
Braun, Manfred,Sacha, Hubert,Galle, Dietmar,El-Alali, Abdullah
, p. 4213 - 4216 (2007/10/02)
The condensation of doubly deprotonated triphenylglycol propionate 4a and imines 1 leads to the formation of trans β-lactams 5 in a diastereoselective and enantioselective manner (85 to > 97percent e.e.).On the other hand, the lithium enolates of the propionates 4b,c, derived from triphenylglycol as well, afford predominantly cis 2-azetidinones 6 in 87 to > 97percent e.e.
