88919-85-1Relevant academic research and scientific papers
Modular counter-Fischer?indole synthesis through radical-enolate coupling
Chung, Hyunho,Kim, Jeongyun,Gonzalez-Montiel, Gisela A.,Cheong, Paul Ha-Yeon,Lee, Hong Geun
supporting information, p. 1096 - 1102 (2021/01/26)
A single-electron transfer mediated modular indole formation reaction from a 2-iodoaniline derivative and a ketone has been developed. This transition-metal-free reaction shows a broad substrate scope and unconventional regioselectivity trends. Moreover, important functional groups for further transformation are tolerated under the reaction conditions. Density functional theory studies reveal that the reaction proceeds by metal coordination, which converts a disfavored 5-endo-trig cyclization to an accessible 7-endo-trig process.
Reactions of 2-(lithiomethyl)phenyl isocyanides with methyl 1-methylindole-3-carboxylate: Elaborations of the adducts of 5H-benz[2,3]azepino[5,6-c]indol-12-one and 2,3′-biindolyl derivatives
Kobayashi, Kazuhiro,Nakai, Daisuke,Fukamachi, Shuhei,Konishi, Hisatoshi
experimental part, p. 2769 - 2776 (2010/04/29)
It has been found that when 2-(Iithiomethyl)phenyl isocyanides were allowed to react with methyl l-methylindole-3-carboxylate, the corresponding 1,4- and/or 1,2-adducts were obtained. The 1,4-adducts could be transformed into 6,11-dihydro-5H-benz[2,3]azep
SYNTHESIS AND SPECTROSCOPIC CHARACTERISTICS OF 2,3'-BIINDOLYLS AND 2,2'-INDOLYLPYRROLES
Bocchi, Vittorio,Palla, Gerardo
, p. 3251 - 3256 (2007/10/02)
A general and selective method has been achieved to synthesize 2,3'-biindolyls and 2,2'-indolylpyrroles through an acid catalyzed reaction of 3-bromoindoles with indoles or pyrroles.I.R., (1)H-NMR, (13)C-NMR and MS data of the dimers are also reported.
A New Procedure for the Synthesis of 2-(2-Indolyl)pyrroles, 2,3'-Bi-indolyls, and 2-(3-Indolyl)-3-(2-indolyl)indoles
Bocchi, Vittorio,Palla, Gerardo
, p. 1074 - 1075 (2007/10/02)
The 3-bromoindoles were found to react with pyrroles and indoles, in the presence of protic or Lewis acids, to give 2-(2-indolyl)pyrroles, 2,3'-bi-indolyls, and trimeric products such as 2-(3-indolyl)-3-(2-indolyl)indoles.
