19012-02-3

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE is used as an intermediate in the synthesis of pharmaceuticals for its potential biological activities and versatile chemical structure. It contributes to the development of new drugs with therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical industry, 1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE serves as a key component in the production of various agrochemicals. Its unique properties allow for the creation of effective compounds for agricultural applications.
Used in Organic Compound Synthesis:
1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE is utilized as a building block in the synthesis of organic compounds, owing to its reactive ketone group and indole structure. It enables the formation of a wide range of organic molecules for various purposes.
Used in Fragrance and Flavor Production:
Leveraging its distinct odor, 1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE is used as a component in the production of fragrances and flavors. It adds unique scents and tastes to various consumer products, enhancing their sensory appeal.
Overall, 1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE's diverse applications across industries such as pharmaceuticals, agrochemicals, organic synthesis, and fragrances and flavors highlight its potential and versatility as a chemical compound.

Upstream product

• 603-76-9 1-methylindole 
• 65610-58-4 1-Methyl-2-chloroindole 
• 75-36-5 acetyl chloride 
• 67-56-1 methanol 
• 99532-45-3 3-acetyl-1-benzenesulfonylindole 
• 123-54-6 acetylacetone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 104142-24-7 3-acetyl-N-(p-toluenesulfonyl)indole 

Downstream Products

• 150114-41-3 1-methylindole-3-acetamide 
• 112122-42-6 1-(1-Methylindol-3-yl)-1-phenyl-ethen 
• 29217-11-6 1-methyl-3-acetylindole s-trans-syn-oxime 
• 3265-24-5 (E)-3-(hydroxyimino)-1-methylindolin-2-one 
• 85729-26-6 N-(1-methyl-1H-indol-3-yl)acetamide 
• 954421-16-0 (2E)-3-(dimethylamino)-1-(1-methyl-1H-indol-3-yl)-2-propen-1-one 
• 1912-48-7 2-(1-methyl-1H-indol-3-yl)acetic acid 
• 155867-11-1 1-methyl-3-[3-(1-benzyl-4-piperidyl)acryloyl] indole 
• 27664-06-8 3-(4-methoxy-phenyl)-1-(1-methyl-indol-3-yl)-propenone 
• 1344706-45-1 3-(4-dimethylamino-phenyl)-1-(1-methyl-1H-indol-3-yl)-prop-2-en-1-one 
• 1237776-26-9 1-(1-methyl-2-(1-phenylethyl)-1H-indol-3-yl)ethanone 
• 199865-36-6 3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole 

Relevant academic research and scientific papers

Acid-catalyzed acylation reaction via C-C bond cleavage: A facile and mechanistically defined approach to synthesize 3-acylindoles

A facile acid-catalyzed acylation of indoles with 1,3-dione as an eco-friendly acylating agent was developed. This protocol combines C-C bond cleavage and heterocyclic C-H bond functionalization to form new C-C bonds. Based on the detailed mechanistic studies, a credible mechanistic pathway was proposed. This journal is

One-pot desulfonylative alkylation of N-sulfonyl azacycles using alkoxides generated by phase-transfer catalysis

Sulfonamide heterocycles, specifically 3-acylindoles, undergo a deprotection/alkylation sequence in the presence of an appropriate alcohol when cesium carbonate or potassium carbonate and a phase-transfer catalyst are utilized. The outcome of the one-pot protocol was found to be significantly dependent on both the alcohol and sulfonamide heterocycle employed. Strictly anhydrous conditions are not necessary for this protocol. Georg Thieme Verlag Stuttgart · New York.

Modulating reactivity and diverting selectivity in palladium-catalyzed heteroaromatic direct arylation through the use of a chloride activating/blocking group

(Chemical Equation Presented) Through the introduction of an aryl chloride substituent, the selectivity of palladium-catalyzed direct arylation may be diverted to provide alternative regioisomeric products in high yields. In cases where low reactivity is typically observed, the presence of the carbon-chlorine bond can serve to enhance reactivity and provide superior outcomes. From a strategic perspective, the C-Cl bond is easily introduced and can be employed in a variety of subsequent transformations to provide a wealth of highly functionalized heterocycles with minimal substrate preactivation. The impact of the C-Cl functional group on direct arylation reactivity has also been evaluated mechanistically, and the observed reactivity profiles correlate very well with that predicted by a concerted metalation-deprotonation pathway.

Towards the syntheses of N-H and N-alkylated derivatives of meridianins

(Chemical Equation Presented) Novel N-H and N-alkylated derivatives of meridianins have been synthesized as potential antitumor agents by a two-step conversion of N-tosyl-3-acetylindoles or N-alkyl-3-acetylindoles to the corresponding enaminones using DMF-DMA, with or without added pyrrolidine. Further cyclization with guanidine gave the corresponding 2-aminopyrimidines. The structures of the compounds, thus obtained, were proved by 1H and 13C NMR spectroscopy, NOE experiments and X-ray analysis.