19012-02-3

Basic information

• Product Name: 1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE
• Synonyms: 1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE;1-Methyl-3-acetylindole;3-Acetyl-1-methylindole;N-Methyl-3-acetylindole;1-(1-Methyl-1H-indole-3-yl)-1-ethanone;1-(1-methyl-3-indolyl)ethanone;1-(1-methylindol-3-yl)ethanone
• CAS NO: 19012-02-3
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21
• Mol File: 19012-02-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 108-109℃
• Boiling Point: 130-140 °C(Press: 0.01 Torr)
• Appearance: /
• Density: 1.09
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE(19012-02-3)
• EPA Substance Registry System: 1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE(19012-02-3)

Safety Data

• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 19012-02-3(Hazardous Substances Data)

Usage

General Description

1-(1-Methyl-1H-indol-3-yl)-1-ethanone is a chemical compound that belongs to the class of indole derivatives. It is a ketone with a molecular formula of C12H13NO and a molecular weight of 187.24 g/mol. 1-(1-METHYL-1H-INDOL-3-YL)-1-ETHANONE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. It has a distinct odor and is often used in the production of fragrances and flavors. The presence of the indole group in the molecule imparts unique properties and potential biological activities. 1-(1-Methyl-1H-indol-3-yl)-1-ethanone has potential applications in various fields due to its versatile properties and structure.

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 104142-24-7 3-acetyl-N-(p-toluenesulfonyl)indole 
• 67-56-1 methanol 
• 99532-45-3 3-acetyl-1-benzenesulfonylindole 
• 123-54-6 acetylacetone 
• 603-76-9 1-methylindole 
• 65610-58-4 1-Methyl-2-chloroindole 
• 75-36-5 acetyl chloride 

Downstream Products

• 150114-41-3 1-methylindole-3-acetamide 
• 112122-42-6 1-(1-Methylindol-3-yl)-1-phenyl-ethen 
• 29217-11-6 1-methyl-3-acetylindole s-trans-syn-oxime 
• 3265-24-5 (E)-3-(hydroxyimino)-1-methylindolin-2-one 
• 85729-26-6 N-(1-methyl-1H-indol-3-yl)acetamide 
• 954421-16-0 (2E)-3-(dimethylamino)-1-(1-methyl-1H-indol-3-yl)-2-propen-1-one 
• 1912-48-7 2-(1-methyl-1H-indol-3-yl)acetic acid 
• 155867-11-1 1-methyl-3-[3-(1-benzyl-4-piperidyl)acryloyl] indole 
• 27664-06-8 3-(4-methoxy-phenyl)-1-(1-methyl-indol-3-yl)-propenone 
• 1344706-45-1 3-(4-dimethylamino-phenyl)-1-(1-methyl-1H-indol-3-yl)-prop-2-en-1-one 
• 1237776-26-9 1-(1-methyl-2-(1-phenylethyl)-1H-indol-3-yl)ethanone 
• 199865-36-6 3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole 

Relevant articles and documents

Acid-catalyzed acylation reaction via C-C bond cleavage: A facile and mechanistically defined approach to synthesize 3-acylindoles

A facile acid-catalyzed acylation of indoles with 1,3-dione as an eco-friendly acylating agent was developed. This protocol combines C-C bond cleavage and heterocyclic C-H bond functionalization to form new C-C bonds. Based on the detailed mechanistic studies, a credible mechanistic pathway was proposed. This journal is

Modulating reactivity and diverting selectivity in palladium-catalyzed heteroaromatic direct arylation through the use of a chloride activating/blocking group

(Chemical Equation Presented) Through the introduction of an aryl chloride substituent, the selectivity of palladium-catalyzed direct arylation may be diverted to provide alternative regioisomeric products in high yields. In cases where low reactivity is typically observed, the presence of the carbon-chlorine bond can serve to enhance reactivity and provide superior outcomes. From a strategic perspective, the C-Cl bond is easily introduced and can be employed in a variety of subsequent transformations to provide a wealth of highly functionalized heterocycles with minimal substrate preactivation. The impact of the C-Cl functional group on direct arylation reactivity has also been evaluated mechanistically, and the observed reactivity profiles correlate very well with that predicted by a concerted metalation-deprotonation pathway.