1484-27-1Relevant articles and documents
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Higa,Scheuer
, p. 395 (1975)
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Fast halogenation of some N-heterocycles by means of N,N'-dihalo-5,5- dimethylhydantoin
Sandtorv, Alexander H.,Bjorsvik, Hans-Rene
, p. 499 - 507 (2013)
An instantaneous, selective and high-yielding halogenation process is reported. The method operates with imidazoles, pyrazoles, and indoles under benign reaction conditions. The developed process involves the use of N,N'-dihalo-5,5-dimethylhydantoins (halo=chlorine, bromine, iodine) as halogenation reagents that are activated by catalytic quantities of a strong Bronsted acid. Moreover, the halogenation process is switchable to produce either the mono- or di-halogenated products. Issues related to the reaction mechanism are investigated and a proposal for a reaction mechanism is disclosed.
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Piers et al.
, p. 2399 (1963)
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Electrochemical umpolung of bromide: Transition-metal-free bromination of indole C–H bond
Zhang, Pan,Chen, Jianbin,Gao, Wei,Xiao, Yiting,Liu, Changwei,Xu, Shanghui,Yan, Xiaoli,Qin, Dawei
, (2019)
A facile and sustainable electrochemical umpolung of bromide ion protocol was developed under mild reaction conditions. Transition metal catalysts and exogenous chemical oxidants were obviated for the bromination of C–H bond. Notably, graphite rod, which is commercially available at supermarkets and is inexpensive, was employed as the electrode material. This operationally easy and environmentally friendly approach accomplished the synthesis of 3-bromoindole in excellent yield and regioselectivity.
QUINOXALINE DERIVATIVES
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Page/Page column 34, (2021/07/24)
The present invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
Synthesis and anti-tumor activity of marine alkaloids
Chen, Guangying,Huang, Gangliang,Zhou, Shiyang
, (2021/04/15)
Marine alkaloids were divided into five categories from the perspective of anti-tumor activity. The optimization process, chemical synthesis, anti-tumor activity evaluation and structure–activity relationship of various compounds were discussed.